PTPN1 anticorps (N-Term)

N° du produit ABIN1882122

Détail du produit anti-PTPN1 anticorps

Antigène: PTPN1 (Protein tyrosine Phosphatase, Non-Receptor Type 1 (PTPN1))

Épitope: AA 23-53, N-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PTPN1 est non-conjugé

Application: Western Blotting (WB)

Homologie: M, Rat

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogène: This PTP1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 23-53 amino acids from the N-terminal region of human PTP1B.

Clone: RB7011

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-PTPN1 (ABIN1882122)

Trümpler, Schlott, Herrlich, Greer, Böhmer: "Calpain-mediated degradation of reversibly oxidized protein-tyrosine phosphatase 1B." dans: The FEBS journal, Vol. 276, Issue 19, pp. 5622-33, (2009) (PubMed).

Xu, Li, Qian, Hong, Shen, Huang: "Reduction of PTP1B by RNAi upregulates the activity of insulin controlled fatty acid synthase promoter." dans: Biochemical and biophysical research communications, Vol. 329, Issue 2, pp. 538-43, (2005) (PubMed).

Blincoe, Chidambaram, Salari, Bond, Evans, Gray-Kaufman, Griffey, Tranby, Garner-Johnson, Lee, Sorenson: "Pharmacokinetic distribution of 67Cu(II)2[3,5-diisopropyl(carboxy-14C)salicylate]4 among murine tissues." dans: Current medicinal chemistry, Vol. 11, Issue 22, pp. 3007-15, (2004) (PubMed).

Wiesmann, Barr, Kung, Zhu, Erlanson, Shen, Fahr, Zhong, Taylor, Randal, McDowell, Hansen: "Allosteric inhibition of protein tyrosine phosphatase 1B." dans: Nature structural & molecular biology, Vol. 11, Issue 8, pp. 730-7, (2004) (PubMed).

Kipfer-Coudreau, Eberlé, Sahbatou, Bonhomme, Guy-Grand, Froguel, Galan, Basdevant, Clément: "Single nucleotide polymorphisms of protein tyrosine phosphatase 1B gene are associated with obesity in morbidly obese French subjects." dans: Diabetologia, Vol. 47, Issue 7, pp. 1278-84, (2004) (PubMed).

Palmer, Bento, Mychaleckyj, Langefeld, Campbell, Norris, Haffner, Bergman, Bowden: "Association of protein tyrosine phosphatase 1B gene polymorphisms with measures of glucose homeostasis in Hispanic Americans: the insulin resistance atherosclerosis study (IRAS) family study." dans: Diabetes, Vol. 53, Issue 11, pp. 3013-9, (2004) (PubMed).

Détails sur PTPN1

Antigène: PTPN1 (Protein tyrosine Phosphatase, Non-Receptor Type 1 (PTPN1))

Autre désignation: PTP1B (PTPN1 Produits)

Synonymes: anticorps PTPN1, anticorps PTP1B, anticorps PTP-1B, anticorps PTP-HA2, anticorps Ptp, anticorps ptp1b, anticorps wu:fk54h03, anticorps CPTP1, anticorps protein tyrosine phosphatase, non-receptor type 1, anticorps protein tyrosine phosphatase, non-receptor type 1 L homeolog, anticorps PTPN1, anticorps Ptpn1, anticorps ptpn1, anticorps ptpn1.L

Sujet: PTP1B is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation.

Poids moléculaire: 49967

NCBI Accession: NP_001265547, NP_002818

UniProt: P18031

Pathways: Signalisation TLR, Response to Growth Hormone Stimulus, ER-Nucleus Signaling, Platelet-derived growth Factor Receptor Signaling