RENT1/UPF1 anticorps (N-Term)

N° du produit ABIN1882125

Détail du produit anti-RENT1/UPF1 anticorps

Antigène: RENT1/UPF1 (UPF1) (UPF1 Regulator of Nonsense Transcripts Homolog (UPF1))

Épitope: AA 7-37, N-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RENT1/UPF1 est non-conjugé

Application: Western Blotting (WB)

Homologie: M

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogène: This RENT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 7-37 amino acids from the N-terminal region of human RENT1.

Clone: RB8018

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-RENT1/UPF1 (ABIN1882125)

Kang, Shen, Macdonald: "Two molecular pathways (NMD and ERAD) contribute to a genetic epilepsy associated with the GABA(A) receptor GABRA1 PTC mutation, 975delC, S326fs328X." dans: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 29, Issue 9, pp. 2833-44, (2009) (PubMed).

Ohnishi, Yamashita, Kashima, Schell, Anders, Grimson, Hachiya, Hentze, Anderson, Ohno: "Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7." dans: Molecular cell, Vol. 12, Issue 5, pp. 1187-200, (2003) (PubMed).

Mendell, ap Rhys, Dietz: "Separable roles for rent1/hUpf1 in altered splicing and decay of nonsense transcripts." dans: Science (New York, N.Y.), Vol. 298, Issue 5592, pp. 419-22, (2002) (PubMed).

Lykke-Andersen: "Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay." dans: Molecular and cellular biology, Vol. 22, Issue 23, pp. 8114-21, (2002) (PubMed).

Carastro, Tan, Selg, Jack, So, Downey: "Identification of delta helicase as the bovine homolog of HUPF1: demonstration of an interaction with the third subunit of DNA polymerase delta." dans: Nucleic acids research, Vol. 30, Issue 10, pp. 2232-43, (2002) (PubMed).

Détails sur RENT1/UPF1

Antigène: RENT1/UPF1 (UPF1) (UPF1 Regulator of Nonsense Transcripts Homolog (UPF1))

Autre désignation: RENT1 (UPF1 Produits)

Synonymes: anticorps HUPF1, anticorps NORF1, anticorps RENT1, anticorps pNORF1, anticorps smg-2, anticorps B430202H16Rik, anticorps PNORF-1, anticorps Rent1, anticorps Upflp, anticorps rent1, anticorps wu:fi40f07, anticorps wu:fj48a01, anticorps zgc:55472, anticorps Tb05.3C6.50, anticorps AO090012000584, anticorps hupf1, anticorps norf1, anticorps pnorf1, anticorps upf1, anticorps UPF1, RNA helicase and ATPase, anticorps UPF1 regulator of nonsense transcripts homolog (yeast), anticorps upf1 regulator of nonsense transcripts homolog (yeast), anticorps regulator of nonsense transcripts 1, anticorps Regulator of nonsense transcripts 1, anticorps UPF1 regulator of nonsense transcripts homolog S homeolog, anticorps UPF1, anticorps Upf1, anticorps upf1, anticorps Tc00.1047053511317.30, anticorps Tb927.5.2140, anticorps TVAG_453890, anticorps TVAG_237840, anticorps AOR_1_1018194, anticorps HPB8_739, anticorps smg-2, anticorps upf1.S

Sujet: RENT1 is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located only in the cytoplasm. When translation ends, it interacts with the protein that is a functional homolog of yeast Upf2p to trigger mRNA decapping.

Poids moléculaire: 124345

NCBI Accession: NP_002902

UniProt: Q92900

Pathways: SARS-CoV-2 Protein Interactome