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RPS6KA6 anticorps (N-Term)

RPS6KA6 Reactivité: Humain, Singe WB, IHC (p) Hôte: Lapin Polyclonal RB0894 unconjugated
N° du produit ABIN1882127
  • Antigène Voir toutes RPS6KA6 Anticorps
    RPS6KA6 (Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 6 (RPS6KA6))
    Épitope
    • 5
    • 4
    • 3
    • 1
    • 1
    • 1
    AA 15-45, N-Term
    Reactivité
    • 25
    • 2
    • 2
    Humain, Singe
    Hôte
    • 18
    • 7
    • 1
    Lapin
    Clonalité
    • 19
    • 7
    Polyclonal
    Conjugué
    • 16
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp RPS6KA6 est non-conjugé
    Application
    • 15
    • 12
    • 6
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Purification
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    Immunogène
    This RSK4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 15-45 amino acids from the N-terminal region of human RSK4.
    Clone
    RB0894
    Isotype
    Ig Fraction
  • Indications d'application
    WB: 1:1000. WB: 1:1000. IHC-P: 1:50~100
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Date de péremption
    6 months
  • Sulzmaier, Young-Robbins, Jiang, Geerts, Prechtl, Matter, Kesari, Ramos: "RSK2 activity mediates glioblastoma invasiveness and is a potential target for new therapeutics." dans: Oncotarget, Vol. 7, Issue 48, pp. 79869-79884, (2018) (PubMed).

    Thakur, Sun, Bollig, Wu, Biliran, Banerjee, Sarkar, Liao: "Anti-invasive and antimetastatic activities of ribosomal protein S6 kinase 4 in breast cancer cells." dans: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 14, Issue 14, pp. 4427-36, (2008) (PubMed).

    Yntema, van den Helm, Kissing, van Duijnhoven, Poppelaars, Chelly, Moraine, Fryns, Hamel, Heilbronner, Pander, Brunner, Ropers, Cremers, van Bokhoven: "A novel ribosomal S6-kinase (RSK4; RPS6KA6) is commonly deleted in patients with complex X-linked mental retardation." dans: Genomics, Vol. 62, Issue 3, pp. 332-43, (2000) (PubMed).

  • Antigène
    RPS6KA6 (Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 6 (RPS6KA6))
    Autre désignation
    RSK4 (RPS6KA6 Produits)
    Synonymes
    anticorps PP90RSK4, anticorps RSK4, anticorps 2610524K04Rik, anticorps RGD1560817, anticorps ribosomal protein S6 kinase A6, anticorps ribosomal protein S6 kinase polypeptide 6, anticorps RPS6KA6, anticorps Rps6ka6
    Sujet
    Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The AGC kinase group consists of 63 kinases including the cyclic nucleotide-regulated protein kinase (PKA & PKG) family, the diacylglycerol-activated/phospholipid-dependent protein kinase C (PKC) family, the related to PKA and PKC (RAC/Akt) protein kinase family, the kinases that phosphorylate G protein-coupled receptors family (ARK), and the kinases that phosphorylate ribosomal protein S6 family (RSK). The calcium/calmodulin-dependent kinase (CAMK) group consists of 75 kinases regulated by Ca2+/CaM and close relative family (CAMK, CAMKL, DAPK, MAPKAPK).
    Poids moléculaire
    83872
    NCBI Accession
    NP_055311
    UniProt
    Q9UK32
    Pathways
    Signalisation MAPK
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