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Phospholamban anticorps (N-Term)

PLN Reactivité: Humain WB Hôte: Lapin Polyclonal RB44799 unconjugated
N° du produit ABIN1882182
  • Antigène Voir toutes Phospholamban (PLN) Anticorps
    Phospholamban (PLN)
    Épitope
    • 30
    • 18
    • 17
    • 9
    • 7
    • 6
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-22, N-Term
    Reactivité
    • 83
    • 24
    • 23
    • 3
    • 2
    • 2
    • 2
    Humain
    Hôte
    • 83
    • 1
    • 1
    Lapin
    Clonalité
    • 83
    • 2
    Polyclonal
    Conjugué
    • 32
    • 6
    • 6
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Cet anticorp Phospholamban est non-conjugé
    Application
    • 32
    • 26
    • 26
    • 25
    • 13
    • 10
    • 9
    • 8
    • 7
    • 6
    • 6
    • 4
    • 1
    Western Blotting (WB)
    Homologie
    B, M, Pig, Rb, Rat
    Purification
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogène
    This PLN antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1-22 amino acids from the N-terminal region of human PLN.
    Clone
    RB44799
    Isotype
    Ig Fraction
    Top Product
    Discover our top product PLN Anticorps primaire
  • Indications d'application
    WB: 1:1000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Date de péremption
    6 months
  • Kaliman, Catalucci, Lam, Kondo, Gutiérrez, Reddy, Palacín, Zorzano, Chien, Ruiz-Lozano: "Myotonic dystrophy protein kinase phosphorylates phospholamban and regulates calcium uptake in cardiomyocyte sarcoplasmic reticulum." dans: The Journal of biological chemistry, Vol. 280, Issue 9, pp. 8016-21, (2005) (PubMed).

    Minamisawa, Sato, Tatsuguchi, Fujino, Imamura, Uetsuka, Nakazawa, Matsuoka: "Mutation of the phospholamban promoter associated with hypertrophic cardiomyopathy." dans: Biochemical and biophysical research communications, Vol. 304, Issue 1, pp. 1-4, (2003) (PubMed).

    McTiernan, Frye, Lemster, Kinder, Ogletree-Hughes, Moravec, Feldman: "The human phospholamban gene: structure and expression." dans: Journal of molecular and cellular cardiology, Vol. 31, Issue 3, pp. 679-92, (1999) (PubMed).

    Fujii, Zarain-Herzberg, Willard, Tada, MacLennan: "Structure of the rabbit phospholamban gene, cloning of the human cDNA, and assignment of the gene to human chromosome 6." dans: The Journal of biological chemistry, Vol. 266, Issue 18, pp. 11669-75, (1991) (PubMed).

  • Antigène
    Phospholamban (PLN)
    Autre désignation
    PLN (PLN Produits)
    Synonymes
    anticorps LOC100226261, anticorps plb, anticorps cmd1p, anticorps CMD1P, anticorps CMH18, anticorps PLB, anticorps Plb, anticorps Plm, anticorps phospholamban, anticorps PLN, anticorps pln, anticorps Pln
    Sujet
    Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2 Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. ATP2A2 inhibition is alleviated by PLN phosphorylation.
    Poids moléculaire
    6109
    UniProt
    P26678
    Pathways
    Negative Regulation of Transporter Activity
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