BUB3 anticorps (C-Term)

N° du produit ABIN1887091

Détail du produit anti-BUB3 anticorps

Antigène: BUB3 (Budding Uninhibited By Benzimidazoles 3 Homolog (Yeast) (BUB3))

Épitope: C-Term

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BUB3 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC)

Purification: Affinity chromatography purified via peptide column

Immunogène: 16 amino acid peptide from near the carboxy terminus of human bub3.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Conseil sur la manipulation: Avoid freezing and thawing repeatly.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Références pour anticorps anti-BUB3 (ABIN1887091)

Jiang, Li, Yang, Hawke, Zheng, Xia, Aldape, Wei, Guo, Chen, Lu: "PKM2 regulates chromosome segregation and mitosis progression of tumor cells." dans: Molecular cell, Vol. 53, Issue 1, pp. 75-87, (2014) (PubMed).

Détails sur BUB3

Antigène: BUB3 (Budding Uninhibited By Benzimidazoles 3 Homolog (Yeast) (BUB3))

Autre désignation: Bub3 (BUB3 Produits)

Synonymes: anticorps BUB3L, anticorps hBUB3, anticorps Aa2-050, anticorps xbub3, anticorps AU019800, anticorps AU021329, anticorps AU043350, anticorps AW146323, anticorps C78067, anticorps BUB3, mitotic checkpoint protein, anticorps BUB3 mitotic checkpoint protein, anticorps BUB3 mitotic checkpoint protein L homeolog, anticorps BUB3, anticorps Bub3, anticorps bub3.L

Sujet: The mitotic checkpoint protein Bub3 is involved with the essential spindle checkpoint pathway which operates during early embryogenesis.Bub3 is important during G2 and early mitosis stages, permitting entry into mitosis depending upon the assembly state of microtubules, thus preventing premature sister chromatid separation, mis-segregation and aneuploidy.Bub3 contains four WD repeat domains and is required for the kinetochore localization of Bub1, a related kinase that is necessary for spindle assembly checkpoint function.Bub1 is able to autophosphorylate and can catalyze the phosphorylation of Bub3.Both Bub1 and Bub3 are mutually dependent for function.Altered Bub expression levels may significantly impair mitotic checkpoint function and is associated with tumor cell proliferation.
Synonyms: Budding uninhibited by benzimidazoles 3, Bub3L

UniProt: O43684

Pathways: Maintenance of Protein Location