PRDM16 anticorps (C-Term)

N° du produit ABIN1887173

Détail du produit anti-PRDM16 anticorps

Antigène: PRDM16 (PR Domain Containing 16 (PRDM16))

Épitope: C-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PRDM16 est non-conjugé

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC)

Purification: Affinity chromatography purified via peptide column

Immunogène: 17 amino acid peptide from near the carboxy terminus of human PRDM16.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Conseil sur la manipulation: Avoid freezing and thawing repeatly.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Détails sur PRDM16

Antigène: PRDM16 (PR Domain Containing 16 (PRDM16))

Autre désignation: PRDM16 (PRDM16 Produits)

Synonymes: anticorps PRDM16, anticorps wu:fc09g08, anticorps MEL1, anticorps PFM13, anticorps 5730557K01Rik, anticorps C130091E20, anticorps csp1, anticorps mKIAA1675, anticorps mel1, anticorps PR/SET domain 16, anticorps PR domain containing 16, anticorps PRDM16, anticorps prdm16, anticorps Prdm16

Sujet: PRDM16 is a zinc finger transcription factor and contains an N-terminal PR domain.The reciprocal translocation t(1,3)(p36,q21) occurs in a subset of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML).This gene is located near the 1p36.3 breakpoint and has been shown to be specifically expressed in the t(1:3)(p36, q21)-positive MDS/AML.The translocation results in the overexpression of a truncated version of this protein that lacks the PR domain, which may play an important role in the pathogenesis of MDS and AML.Recent studies have shown that PRDM16 normally acts as a Smad3 binding protein that may be important for the development of orofacial structures through modulation of the TGF-beta signaling pathway.Other experiments have indicated that PRDM16 controls a bidirectional cell fate switch between skeletal myoblasts and brown fat cells.
Synonyms: PR domain containing 16, MEL1, PFM13

Pathways: Stem Cell Maintenance, Brown Fat Cell Differentiation