GEMC1 anticorps (Center)

N° du produit ABIN1887716

Détail du produit anti-GEMC1 anticorps

Antigène: GEMC1 (GMNC) (Geminin Coiled-Coil Domain Containing (GMNC))

Épitope: Center

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GEMC1 est non-conjugé

Application: Western Blotting (WB), ELISA

Purification: Affinity chromatography purified via peptide column

Immunogène: 19 amino acid peptide near the center of human GEMC1.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Conseil sur la manipulation: Avoid freezing and thawing repeatly.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Détails sur GEMC1

Antigène: GEMC1 (GMNC) (Geminin Coiled-Coil Domain Containing (GMNC))

Autre désignation: GEMC1 (GMNC Produits)

Synonymes: anticorps GEMC1, anticorps Gemc1, anticorps Gm1778, anticorps Gm606, anticorps gemc1, anticorps xGEMC1, anticorps geminin coiled-coil domain containing, anticorps geminin coiled-coil domain containing S homeolog, anticorps GMNC, anticorps Gmnc, anticorps gmnc.S

Sujet: The Geminin coiled-coil domain-containing protein 1 (GEMC1) is a highly conserved protein that is required for chromosomal replication.GEMC1 contains a region similar to the coiled-coil domain of geminin, an essential vertebrate replication protein in which the coiled-coil domain is required for the function.GEMC1 binds to the checkpoint and replication factor TopBP1, allowing the binding of GEMC1 to chromatin during pre-replication complex formation.GEMC1 also directly interacts with replication factors Cdc45 and Cdk2-CyclinE and stimulates the initiation of DNA replication.Depletion of GEMC1 by siRNA in embryonic and somatic vertebrate cells prevents DNA replication due to impairment of Cdc45 loading onto chromatin, suggesting GEMC1 promotes initiation of DNA replication by mediating TopBP1 and Cdk2 dependent recruitment of Cdc45 onto replication origins.
Synonyms: Geminin coiled-coil domain-containing protein 1

NCBI Accession: NP_001140158