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CD21 anticorps (PE)

CR2 Reactivité: Humain, Porc, Boeuf (Vache), Chien FACS Hôte: Souris Monoclonal LT21 PE
N° du produit ABIN192225
  • Antigène Voir toutes CD21 (CR2) Anticorps
    CD21 (CR2) (Complement Component (3d/Epstein Barr Virus) Receptor 2 (CR2))
    Reactivité
    • 133
    • 28
    • 27
    • 15
    • 13
    • 10
    • 8
    • 8
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Humain, Porc, Boeuf (Vache), Chien
    Hôte
    • 86
    • 70
    • 12
    Souris
    Clonalité
    • 108
    • 59
    • 1
    Monoclonal
    Conjugué
    • 72
    • 22
    • 16
    • 16
    • 9
    • 5
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp CD21 est conjugé à/à la PE
    Application
    • 116
    • 66
    • 52
    • 40
    • 30
    • 29
    • 27
    • 16
    • 15
    • 6
    • 6
    • 6
    • 6
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    Flow Cytometry (FACS)
    Specificité
    The antibody LT21 reacts with an extracellular epitope of CD21 (CR2), a 145 kDa transmembrane glycoprotein (complement C3d receptor - C3dR) expressed on B lymphocytes, follicular dendritic cells, some epithelial cells and a subsets of T lymphocytes. It is not expressed on immature B cells.
    Réactivité croisée (Details)
    Human, Porcine, Bovine, Canine (Dog)
    Purification
    Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
    Immunogène
    IM9 human B-lymphoblastoid cell line
    Clone
    LT21
    Isotype
    IgG1
    Top Product
    Discover our top product CR2 Anticorps primaire
  • Indications d'application
    Flow cytometry: The reagent is designed for analysis of human blood cells using 20 μL reagent / 100 μL of whole blood or 106 cells in a suspension. The content of a vial (2 ml) is sufficient for 100 tests.
    Commentaires

    The purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use. No reconstitution is necessary.

    Restrictions
    For Research Use only
  • Reconstitution
    No reconstitution is necessary.
    Buffer
    Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Do not freeze.
    Avoid prolonged exposure to light.
    Stock
    4 °C
    Stockage commentaire
    Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
  • Filatov, Krotov, Zgoda, Volkov: "Fluorescent immunoprecipitation analysis of cell surface proteins: a methodology compatible with mass-spectrometry." dans: Journal of immunological methods, Vol. 319, Issue 1-2, pp. 21-33, (2007) (PubMed).

    Faldyna, Samankova, Leva, Cerny, Oujezdska, Rehakova, Sinkora: "Cross-reactive anti-human monoclonal antibodies as a tool for B-cell identification in dogs and pigs." dans: Veterinary immunology and immunopathology, Vol. 119, Issue 1-2, pp. 56-62, (2007) (PubMed).

  • Antigène
    CD21 (CR2) (Complement Component (3d/Epstein Barr Virus) Receptor 2 (CR2))
    Autre désignation
    CD21 (CR2 Produits)
    Synonymes
    anticorps C3DR, anticorps CD21, anticorps CR, anticorps CVID7, anticorps SLEB9, anticorps Cd21, anticorps cd21, anticorps CR1, anticorps CR1-L, anticorps CR2, anticorps complement C3d receptor 2, anticorps complement C3b/C4b receptor 1 (Knops blood group), anticorps CR2, anticorps Cr2, anticorps CR1
    Sujet
    Complement C3d receptor 2,CD21 (complement receptor 2, CR2) binds C3 complement fragments, especially its breakdown fragments, which remain covalently attached to complement activating surfaces or antigen. CD21 has important roles in uptake and retention of immunocomplexes, survival of memory B cells and in development and maintenance of the humoral response to T-dependent antigens. CD21 also serves as a key receptor for Epstein-Barr virus binding and is involved in targeting prions to folicular dendritic cells and expediting neuroinvasion following peripheral exposure to prions. A soluble form of the CD21 (sCD21) is shed from the lymphocyte surface and retains its ability to bind respective ligands.,CR2, C3DR2, CVID7, SLEB9
    ID gène
    1380
    UniProt
    P20023
    Pathways
    Système du Complément
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