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TNFRSF8 anticorps (PE)

TNFRSF8 Reactivité: Humain FACS Hôte: Souris Monoclonal MEM-268 PE
N° du produit ABIN192354
  • Antigène Voir toutes TNFRSF8 Anticorps
    TNFRSF8 (Tumor Necrosis Factor Receptor Superfamily, Member 8 (TNFRSF8))
    Reactivité
    • 138
    • 31
    • 18
    • 16
    Humain
    Hôte
    • 90
    • 63
    • 14
    • 4
    • 1
    Souris
    Clonalité
    • 99
    • 71
    • 2
    Monoclonal
    Conjugué
    • 73
    • 14
    • 12
    • 12
    • 7
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Cet anticorp TNFRSF8 est conjugé à/à la PE
    Application
    • 104
    • 61
    • 60
    • 47
    • 38
    • 27
    • 26
    • 25
    • 13
    • 8
    • 6
    • 6
    • 6
    • 5
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Flow Cytometry (FACS)
    Specificité
    The antibody MEM-268 recognizes extracellular part of CD30 (Ki-1 antigen), a 105 kDa single chain glycoprotein expressed on Hodgkin's and Reed-Sternberg cells, it is also found in Burkitt's lymphomas, virus-infected T and B lymphocytes, and on normal B and T lymphocytes after activation (T lymphocytes that produce Th2-type cytokines and on CD4+/CD8+ T lymphocytes that co-express CD45RO and the IL4 receptor).
    Réactivité croisée (Details)
    Human
    Purification
    Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
    Immunogène
    Expression vector containing CD30 cDNA (booster suspension of THP-1 cell line)
    Clone
    MEM-268
    Isotype
    IgG
    Top Product
    Discover our top product TNFRSF8 Anticorps primaire
  • Indications d'application
    Flow cytometry: The reagent is designed for analysis of human blood cells using 20 μL reagent / 100 μL of whole blood or 106 cells in a suspension. The content of a vial (2 ml) is sufficient for 100 tests.
    Commentaires

    The purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use. No reconstitution is necessary.

    Restrictions
    For Research Use only
  • Reconstitution
    No reconstitution is necessary.
    Buffer
    Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Do not freeze.
    Avoid prolonged exposure to light.
    Stock
    4 °C
    Stockage commentaire
    Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
  • Pavlov, Martins, Delgado: "Development and validation of a fluorescent microsphere immunoassay for soluble CD30 testing." dans: Clinical and vaccine immunology : CVI, Vol. 16, Issue 9, pp. 1327-31, (2009) (PubMed).

  • Antigène
    TNFRSF8 (Tumor Necrosis Factor Receptor Superfamily, Member 8 (TNFRSF8))
    Autre désignation
    CD30 (TNFRSF8 Produits)
    Synonymes
    anticorps CD30, anticorps D1S166E, anticorps Ki-1, anticorps Cd30, anticorps Ki, anticorps TNFRSF8, anticorps TNF receptor superfamily member 8, anticorps tumor necrosis factor receptor superfamily, member 8, anticorps TNFRSF8, anticorps Tnfrsf8
    Sujet
    TNF receptor superfamily member 8,CD30 is a type I transmembrane glycoprotein of the TNF receptor superfamily. CD30 was originally identified as a cell surface antigen of Hodgkins and Reed-Sternberg cells using monoclonal antibody Ki-1. The ligand for CD30 is CD30L (CD153). The binding of CD30 to CD30L mediates pleiotropic effects including cell proliferation, activation, differentiation, and apoptotic cell death. CD30 has a critical role in the pathophysiology of Hodgkin's disease and other CD30+ lymphomas. CD30 acts as a costimulatory molecule in thymic negative selection. In addition to its expression on Hodgkin's and Reed-Sternberg cells, CD30 is also found in some non-Hodgkin's lymphomas (including Burkitt's lymphomas), virus-infected T and B cells, and on normal T and B cells after activation. In T cells, CD30 expression is present on a subset of T cells that produce Th2-type cytokines and on CD4+/CD8+ thymocytes that co-express CD45RO and the IL4 receptor. Soluble form of CD30 (sCD30) serves as a marker reflecting Th2 immune response.,Ki-1, TNFRSF8, CD30L receptor, D1S166E
    ID gène
    943
    UniProt
    P28908
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