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TNFRSF10B anticorps (Extracellular Domain) (PE)

TNFRSF10B Reactivité: Humain FACS Hôte: Souris Monoclonal DR5-01-1 PE
N° du produit ABIN192359
  • Antigène Voir toutes TNFRSF10B Anticorps
    TNFRSF10B (Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B))
    Épitope
    • 15
    • 7
    • 5
    • 5
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Extracellular Domain
    Reactivité
    • 99
    • 20
    • 4
    • 1
    • 1
    Humain
    Hôte
    • 64
    • 39
    • 3
    • 2
    • 1
    • 1
    • 1
    Souris
    Clonalité
    • 61
    • 47
    • 2
    Monoclonal
    Conjugué
    • 73
    • 11
    • 6
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp TNFRSF10B est conjugé à/à la PE
    Application
    • 75
    • 36
    • 31
    • 26
    • 17
    • 16
    • 15
    • 13
    • 12
    • 12
    • 8
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Flow Cytometry (FACS)
    Specificité
    The mouse monoclonal antibody DR5-01-1 recognizes an extracellular domain of TRAIL-R2 (DR5). TRAIL-R2 is one of two TNF superfamily members that contain death domain for TRAIL (APO2L).
    Réactivité croisée (Details)
    Human
    Purification
    Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
    Immunogène
    Recombinant fusion protein of human IgG heavy chain and extracellular domain of DR5.
    Clone
    DR5-01-1
    Isotype
    IgG1
    Top Product
    Discover our top product TNFRSF10B Anticorps primaire
  • Indications d'application
    Flow cytometry: Recommended dilution: 1-5 μg/mL, positive control: JURKAT human peripheral blood leukemia T cell line.
    Commentaires

    The purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography.

    Restrictions
    For Research Use only
  • Concentration
    0.1 mg/mL
    Buffer
    Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Do not freeze.
    Avoid prolonged exposure to light.
    Stock
    4 °C
    Stockage commentaire
    Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
  • Vondálová Blanárová, Jelínková, Szöor, Skender, Soucek, Horváth, Vaculová, Andera, Sova, Szöllosi, Hofmanová, Vereb, Kozubík: "Cisplatin and a potent platinum(IV) complex-mediated enhancement of TRAIL-induced cancer cells killing is associated with modulation of upstream events in the extrinsic apoptotic pathway." dans: Carcinogenesis, Vol. 32, Issue 1, pp. 42-51, (2010) (PubMed).

  • Antigène
    TNFRSF10B (Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B))
    Autre désignation
    CD262 / TRAIL-R2 (TNFRSF10B Produits)
    Synonymes
    anticorps TNFRSF10B, anticorps dr5, anticorps cd262, anticorps killer, anticorps trick2, anticorps trickb, anticorps xDR-M1, anticorps xDR-M2, anticorps ztnfr9, anticorps trailr2, anticorps trick2a, anticorps trick2b, anticorps CD262, anticorps DR5, anticorps KILLER, anticorps KILLER/DR5, anticorps TRAIL-R2, anticorps TRAILR2, anticorps TRICK2, anticorps TRICK2A, anticorps TRICK2B, anticorps TRICKB, anticorps ZTNFR9, anticorps Ly98, anticorps MK, anticorps tumor necrosis factor receptor superfamily, member 10b, anticorps tumor necrosis factor receptor superfamily member 10b S homeolog, anticorps tumor necrosis factor receptor superfamily member 10b L homeolog, anticorps tumor necrosis factor receptor superfamily member 10b, anticorps TNF receptor superfamily member 10b, anticorps Tnfrsf10b, anticorps TNFRSF10B, anticorps tnfrsf10b.S, anticorps tnfrsf10b.L, anticorps tnfrsf10b
    Sujet
    TNF receptor superfamily member 10b,TRAIL-R2 (CD262, DR5) is one of two TNF superfamily member intracellular death domain containing receptors for TRAIL (APO2L). Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including tumor necrosis factor (TNF) and Fas ligand in the TNF family through their death domain containing receptors, TNF receptor 1 (TNFR1) and Fas, respectively. Another member in the TNF family has been identified and designated TRAIL (for TNF related apoptosis inducing ligand) and Apo2L (for Apo2 ligand). Receptors for TRAIL include two death domain containing receptors, DR4 and DR5, as well as two decoy receptors, DcR1 and DcR2, lacking the intracellular signaling death domain. DcR1 (also called TRID), like the related death receptors DR4 and DR5, contains two extracellular cysteine rich domains. However, DcR1 contains no intracellular death domain and is thus incapable of signaling apoptosis. It has been suggested DcR1 is responsible for TRAIL resistance in normal human tissues including heart, placenta, lung, liver, kidney, spleen, and bone marrow. DR5 is a member of the TNF receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor related apoptosis inducing ligand (TNFSF10/TRAIL/APO2L), and transduces apoptosis signal. Studies with FADD deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein.,TNFRSF10B, KILLER, TRICK2, TRAIL-R2
    ID gène
    8795
    UniProt
    O14763
    Pathways
    Signalisation p53, Apoptose, Positive Regulation of Endopeptidase Activity
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