BBS5 anticorps (AA 108-141)

N° du produit ABIN1944771

Détail du produit anti-BBS5 anticorps

Antigène: BBS5 (Bardet-Biedl Syndrome 5 (BBS5))

Épitope: AA 108-141

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BBS5 est non-conjugé

Application: Western Blotting (WB)

Homologie: Pr, M

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This BBS5 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 108-141 amino acids from the Central region of human BBS5.

Clone: RB47475

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-BBS5 (ABIN1944771)

Hillier, Graves, Fulton, Fulton, Pepin, Minx, Wagner-McPherson, Layman, Wylie, Sekhon, Becker, Fewell, Delehaunty, Miner, Nash, Kremitzki, Oddy, Du, Sun, Bradshaw-Cordum, Ali, Carter, Cordes, Harris et al.: "Generation and annotation of the DNA sequences of human chromosomes 2 and 4. ..." dans: Nature, Vol. 434, Issue 7034, pp. 724-31, (2005) (PubMed).

Li, Gerdes, Haycraft, Fan, Teslovich, May-Simera, Li, Blacque, Li, Leitch, Lewis, Green, Parfrey, Leroux, Davidson, Beales, Guay-Woodford, Yoder, Stormo, Katsanis, Dutcher: "Comparative genomics identifies a flagellar and basal body proteome that includes the BBS5 human disease gene." dans: Cell, Vol. 117, Issue 4, pp. 541-52, (2004) (PubMed).

Détails sur BBS5

Antigène: BBS5 (Bardet-Biedl Syndrome 5 (BBS5))

Autre désignation: BBS5 (BBS5 Produits)

Synonymes: anticorps zgc:56578, anticorps 1700049I01Rik, anticorps 2700023J09Rik, anticorps Bardet-Biedl syndrome 5, anticorps Bardet-Biedl syndrome 5 (human), anticorps bbs5, anticorps BBS5, anticorps Bbs5

Sujet: The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for BBSome complex ciliary localization but not for the proper complex assembly.

Poids moléculaire: 38755

ID gène: 129880

UniProt: Q8N3I7

Pathways: Signalisation Hedgehog