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GRIN1/NMDAR1 anticorps (AA 900-950)

GRIN1 Reactivité: Humain, Rat, Souris WB, FACS Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN2017602
  • Antigène Voir toutes GRIN1/NMDAR1 (GRIN1) Anticorps
    GRIN1/NMDAR1 (GRIN1) (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 1 (GRIN1))
    Épitope
    • 34
    • 27
    • 22
    • 17
    • 15
    • 5
    • 5
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 900-950
    Reactivité
    • 132
    • 126
    • 101
    • 6
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain, Rat, Souris
    Hôte
    • 135
    • 32
    • 1
    • 1
    Lapin
    Clonalité
    • 128
    • 41
    Polyclonal
    Conjugué
    • 72
    • 10
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 6
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    Cet anticorp GRIN1/NMDAR1 est non-conjugé
    Application
    • 120
    • 58
    • 42
    • 41
    • 40
    • 28
    • 20
    • 18
    • 13
    • 10
    • 10
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Flow Cytometry (FACS)
    Specificité
    NMDAR1 Antibody detects endogenous levels of mouse NMDAR1. It is predicted to react with human and rat NMDAR1 protein according to sequence homology.Positive Control: Mouse brain
    Réactivité croisée (Details)
    NMDAR1 Antibody detects endogenous levels of mouse NMDAR1. It is predicted to react with human and rat NMDAR1 protein according to sequence homology.Positive Control: Mouse brain
    Purification
    Immunoaffinity chromatography
    Immunogène
    KLH-coupled synthetic peptide within AA 900-950 of human NMDAR1
    Isotype
    IgG2a
    Top Product
    Discover our top product GRIN1 Anticorps primaire
  • Indications d'application
    Working concentrations for specific applications should be determined by the investigator. The appropriate concentrations may be affected by secondary antibody affinity, antigen concentration, the sensitivity of the method of detection, temperature, the length of the incubations, and other factors. The suitability of this antibody for applications other than those listed below has not been determined. The following concentration ranges are recommended starting points for this product.
    Western blot: 0.5-1 µg/mLFlow cytometry: 1-3 µg for 1 x 106 cellsOther applications: user-optimized
    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Buffer
    PBS, pH 7.4, containing 0.02 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    The antibody is stable in lyophilized form if stored at -20°C or below. The reconstituted antibody can be stored for 2-3 weeks at 2-8°C. For long term storage, aliquot and store at -20°C or below. Avoid repeated freezing and thawing cycles.
  • Antigène
    GRIN1/NMDAR1 (GRIN1) (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 1 (GRIN1))
    Autre désignation
    NMDAR1 (GRIN1 Produits)
    Synonymes
    anticorps GluN1, anticorps MRD8, anticorps NMDA1, anticorps NMDAR1, anticorps NR1, anticorps nmda1, anticorps nmdar1, anticorps GB19253, anticorps GRIN1, anticorps NMD-R1, anticorps Z16, anticorps GluRdelta1, anticorps GluRzeta1, anticorps M100174, anticorps Nmdar, anticorps Rgsc174, anticorps NMDAR1.1, anticorps zgc:152678, anticorps glutamate ionotropic receptor NMDA type subunit 1, anticorps glutamate receptor, ionotropic, N-methyl D-aspartate 1 S homeolog, anticorps NMDA receptor 1, anticorps G protein-regulated inducer of neurite outgrowth 1, anticorps glutamate receptor, ionotropic, NMDA1 (zeta 1), anticorps glutamate receptor, ionotropic, N-methyl D-aspartate 1a, anticorps GRIN1, anticorps grin1.S, anticorps grin1, anticorps Grin1, anticorps Nmdar1, anticorps Gprin1, anticorps grin1a
    Sujet
    N-methyl-D-aspartate receptor (NMDAR) forms a heterodimer of at least one NMDAR1 and one NR2A-D subunit. NMDAR1 subunits and NR2 subunits bind to the co-agonist glycine and the neurotransmitter glutamate, respectively.'PKC'an phosphorylate NMDAR1 of the receptor at Ser890/Ser896, and PKA can phosphorylate NMDAR1 at Ser897. The phosphorylation of NMDAR1 by'PKC'ecreases its affinity for calmodulin, thus preventing the inhibitory effect of calmodulin on NMDAR. The phosphorylation of NMDAR1 by PKA probably counteracts the inhibitory effect of calcineurin on the receptor.
    NMDAR1 Antibody is developed in rabbit using a KLH-coupled synthetic peptide within residues 900-950 of human NMDAR1 (Swiss Prot: Q05586).
    Pathways
    Synaptic Membrane, Feeding Behaviour, Regulation of long-term Neuronal Synaptic Plasticity
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