HPV16 E7 anticorps (Middle Region)

N° du produit ABIN2173795

Détail du produit anti-HPV16 E7 anticorps

Antigène: HPV16 E7 (HPV-16 E7) (Human Papilloma Virus 16 E7 (HPV-16 E7))

Épitope: Middle Region

Reactivité: Human Papillomavirus 16 (HPV-16)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HPV16 E7 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), ELISA, Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC)

Specificité: This antibody may also detect HPV35-E7

Réactivité croisée: Humain, Virus

Réactivité croisée (Details): HPV16

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from middle of HPV16-E7

Isotype: IgG

Information d'application

Indications d'application: WB 1:100-1000
IHC-P 1:100-500
IF(IHC-P) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Références pour anticorps anti-HPV16 E7 (ABIN2173795)

Liu, Murray-Stewart, Casero, Kagiampakis, Jin, Zhang, Wang, Che, Tong, Ke, Jiang, Wang, Wan: "Targeting hexokinase 2 inhibition promotes radiosensitization in HPV16 E7-induced cervical cancer and suppresses tumor growth." dans: International journal of oncology, Vol. 50, Issue 6, pp. 2011-2023, (2017) (PubMed).

Shao, Sun, Wang, Chung, Du, Wang, Qiu, Wang, Wu: "HPV16 E6/E7 upregulates HIF-2α and VEGF by inhibiting LKB1 in lung cancer cells." dans: Tumour biology, Vol. 39, Issue 7, pp. 1010428317717140, (2017) (PubMed).

Détails sur HPV16 E7

Antigène: HPV16 E7 (HPV-16 E7) (Human Papilloma Virus 16 E7 (HPV-16 E7))

Abstract: HPV-16 E7 Produits

Synonymes: anticorps transforming protein E7, anticorps E7

Classe de substances: Viral Protein

Sujet:

Synonyms: Protein E7, E7

Background: Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. E7 protein has both transforming and trans-activating activities. Induces the disassembly of the E2F1 transcription factor from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes. Interferes with host histone deacetylation mediated by HDAC1 and HDAC2, leading to transcription activation. Plays also a role in the inhibition of both antiviral and antiproliferative functions of host inteferon alpha.

ID gène: 1489079

UniProt: P03129