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IL2RG anticorps (AA 51-150)

IL2RG Reactivité: Humain, Rat WB, FACS, ELISA Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN2176981
  • Antigène Voir toutes IL2RG Anticorps
    IL2RG (Interleukin 2 Receptor, gamma (IL2RG))
    Épitope
    • 15
    • 7
    • 7
    • 6
    • 6
    • 5
    • 5
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 51-150
    Reactivité
    • 71
    • 28
    • 24
    • 4
    • 1
    Humain, Rat
    Hôte
    • 59
    • 13
    • 9
    Lapin
    Clonalité
    • 62
    • 19
    Polyclonal
    Conjugué
    • 34
    • 11
    • 5
    • 5
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp IL2RG est non-conjugé
    Application
    • 53
    • 33
    • 27
    • 8
    • 5
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Flow Cytometry (FACS), ELISA
     Réactivité croisée
    Humain, Rat
    Homologie
    Mouse,Dog,Cow,Pig
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from human IL-2R gamma
    Isotype
    IgG
  • Indications d'application
    WB 1:300-5000
    ELISA 1:500-1000
    FCM 1:20-100
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Date de péremption
    12 months
  • Antigène
    IL2RG (Interleukin 2 Receptor, gamma (IL2RG))
    Autre désignation
    IL-2R gamma (IL2RG Produits)
    Synonymes
    anticorps Ab2-183, anticorps Cd132, anticorps CD132, anticorps CIDX, anticorps IL-2RG, anticorps IMD4, anticorps P64, anticorps SCIDX, anticorps SCIDX1, anticorps [g]c, anticorps gamma(c), anticorps gc, anticorps interleukin 2 receptor subunit gamma, anticorps interleukin 2 receptor subunit gamma L homeolog, anticorps interleukin 2 receptor, gamma chain, anticorps IL2RG, anticorps il2rg.L, anticorps Il2rg
    Sujet

    Synonyms: P64, CIDX, IMD4, CD132, SCIDX, IL-2RG, SCIDX1, Cytokine receptor common subunit gamma, Interleukin-2 receptor subunit gamma, IL-2 receptor subunit gamma, IL-2R subunit gamma, gammaC, IL2RG

    Background: Interleukin 2 (IL2) receptor gamma chain (IL5212R gamma) is a cell surface glycoprotein expressed by a variety of leukocytes including T cells, B cells, NK cells, monocytes, macrophages, and neutrophils. IL2R gamma is also known as CD132, common cytokine receptor gamma chain, and gamma c. IL2R gamma forms complexes with other cell surface proteins including CD25 (IL2R alpha), CD122 (IL2R beta), CD124 (IL4R alpha), CD127 (IL7R), and others. IL2R gamma complexed with other cell surface proteins forms receptors for the cytokines IL2, IL4, IL7, IL9, and IL15. Acting through the IL2R gamma containing complexes, these cytokines regulate lymphocyte development and activation. Chemical cross linking experiments reveal that IL2R gamma is able to bind cytokines only when complexed with these other cell surface proteins. In addition to interacting with other cell surface glycoproteins, IL2R gamma associates with several cytoplasmic tyrosine kinases including JAK3 (Janus Kinase 3), JAK1, Syc, and Lyc. Cytokine binding to the IL2R gamma containing receptor complexes activates these tyrosine kinases. Once activated, these tyrosine kinases phosphorylate their associated receptors, creating docking sites for signaling molecules such as PI 3 kinase. The activated tyrosine kinases also phosphorylate downstream regulators including STAT3 (Signal Transducer and Activator of Transcription 3), STAT5, and STAT6. The various cytokines that bind to IL2R gamma containing receptor complexes exert their effects through unique repertoires of cytoplasmic signaling molecules. IL2, IL7, and IL9 exert their effects through cascades, which activate STAT3 and STAT5, while IL4 activates STAT6. IL2 and IL15 exert their effects through cascades, which activate the MAP kinase cascade. IL7 exerts its effects through a cascade that results in VDJ immunoglobulin gene rearrangement.

    ID gène
    3561
    UniProt
    P31785
    Pathways
    Signalistation JAK/STAT, Growth Factor Binding
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