JAM3 anticorps

N° du produit ABIN2191807

Détail du produit anti-JAM3 anticorps

Antigène: JAM3 (Junctional Adhesion Molecule 3 (JAM3))

Reactivité: Souris

Hôte: Rat

Clonalité: Monoclonal

Conjugué: Cet anticorp JAM3 est non-conjugé

Application: Immunoprecipitation (IP), Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunoassay (IA), Detection (D), Inhibition Assay (InhA)

Stérilité: 0.2 μm filtered

Clone: CRAM-18 F26

Information d'application

Indications d'application: For immunohistology and flow cytometry, dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50. For inhibition of biological activity, dilutions have to be made according to the amounts of JAM-C to be inhibited.

Restrictions: For Research Use only

Stockage

Buffer: PBS, containing 0.1 % bovine serum albumin.

Stock: 4 °C

Stockage commentaire: Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.

Date de péremption: 12 months

Références pour anticorps anti-JAM3 (ABIN2191807)

Johnson-Léger, Aurrand-Lions, Beltraminelli, Fasel, Imhof: "Junctional adhesion molecule-2 (JAM-2) promotes lymphocyte transendothelial migration." dans: Blood, Vol. 100, Issue 7, pp. 2479-86, (2002) (PubMed).

Détails sur JAM3

Antigène: JAM3 (Junctional Adhesion Molecule 3 (JAM3))

Autre désignation: Junctional Adhesion Molecule-C (JAM3 Produits)

Synonymes: anticorps JAM3, anticorps jam3, anticorps sr:nyz155, anticorps wu:fb30h11, anticorps wu:fc08c06, anticorps wu:fc13e04, anticorps wu:fc25g11, anticorps jamc.2, anticorps 1110002N23Rik, anticorps JAM-3, anticorps JAM-C, anticorps Jcam3, anticorps JAM-2, anticorps JAMC, anticorps junctional adhesion molecule 3, anticorps junctional adhesion molecule 3b, anticorps junctional adhesion molecule 3a, anticorps junction adhesion molecule 3, anticorps JAM3, anticorps jam3b, anticorps jam3a, anticorps Jam3

Sujet: The monoclonal antibody CRAM-18 F26 recognizes junctional adhesion molecule-C (JAM-C) also known as JAM-2, a 45 kD cell adhesion molecule (CAM). JAM-C is a transmembrane protein which is a member of the immunoglobulin superfamily found at intercellular junctions of endothelial cells. JAM-C belongs together with JAM-A (JAM or JAM-1) and JAM-B (VE-JAM or JAM-3) to a family of adhesion proteins with a V-C2 immunoglobulin domain organization. JAM plays an important role in tight junctions where it is involved in cell-to-cell adhesion through homophilic interaction. It codistributes with other tight junction components as ZO-1, 7H6 antigen, cingulin and occludin. JAM-C is potentially involved in the junctional sealing of the vascular endothelium, in particular of high endothelial venules (HEV). In adult murine tissue JAM-C expression is reported to be restricted to high endothelial venules of lymphoid organs, lymphoendothelial cells and endothelial cells in kidney. Monoclonal antibody CRAM-18 F26 also reacts with human JAM-C. In humans, JAM-C expression is not restricted to endothelial cells, but is also expressed on human lymphocytes.