C3AR1 anticorps

N° du produit ABIN2192050

Détail du produit anti-C3AR1 anticorps

Antigène: C3AR1 (Complement Component 3a Receptor 1 (C3AR1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp C3AR1 est non-conjugé

Application: Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro))

Stérilité: 0.2 μm filtered

Clone: 17 (hC3aRZ8)

Information d'application

Indications d'application: is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50. Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.

Restrictions: For Research Use only

Stockage

Buffer: PBS, containing 0.02 % sodium azide and 0.1 % bovine serum albumin.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Détails sur C3AR1

Antigène: C3AR1 (Complement Component 3a Receptor 1 (C3AR1))

Abstract: C3AR1 Produits

Synonymes: anticorps C3AR, anticorps C3a-R, anticorps c3ar1, anticorps AZ3B, anticorps HNFAG09, anticorps C3a anaphylatoxin chemotactic receptor, anticorps complement C3a receptor 1, anticorps complement component 3a receptor 1, anticorps c3ar1, anticorps C3AR1, anticorps C3ar1

Sujet: The monoclonal antibody 17 reacts with the human receptor for C3a. The monoclonal antibody 17 is in the literature also referred to as clone hC3aRZ8. In the course of complement activation the C3a receptor functions as the cell surface receptor for the anaphylatoxin C3a, the C-terminal 77 amino acid cleavage product of the alpha chain of C3, but not for C3a-desArg. All cellular responses to C3a are specifically mediated by interactions with the membrane bound C3a receptor, a seven transmembrane GTP-binding-protein-coupled receptor that belongs to the rhodopsin supergene family. The 54 kDa C3a receptor is widely distributed in, myeloid cells, peripheral tissues and the central nervous system. Expression of C3aR has been demonstrated on neutrophils, monocytes, eosinophils, astrocytes, neurons and glial cells and is increased in inflammatory conditions. No C3aR expression was detectable on lymphocytes and on tonsillar B cells even after stimulation.

Pathways: Système du Complément