IL1R2 anticorps (Interleukin 1 Receptor, Type II)

Details for Product anti-IL1R2 Antibody No. ABIN2192218
Antigène
  • CD121b
  • CDw121b
  • IL-1R-2
  • IL-1RT-2
  • IL-1RT2
  • IL1R2c
  • IL1RB
  • Il1r-2
  • IL-1R2
  • interleukin 1 receptor type 2
  • interleukin 1 receptor, type II
  • IL1R2
  • Il1r2
Reactivité
Humain
148
33
26
2
1
Hôte
Souris
103
46
12
1
1
Clonalité (Clone)
Monoclonal ()
Conjugué
Cet anticorp IL1R2 est non-conjugé
7
5
5
5
4
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
Application
Immunoassay (IA), Flow Cytometry (FACS), Western Blotting (WB)
93
81
21
20
14
13
12
11
8
8
4
3
2
2
1
1
1
1
Options
Clone 8-5
Stérilité 0.2 μm filtered
Plasmids, Primers & others Plasmids, Primers & others IL1R2 products on genomics-online (e.g. as negative or positive controls)
Antigène
Sujet The antibody reacts specificly with Human IL-1 R II. The IL-1 system includes two agonists (IL-1alpha and IL-1beta), converting enzymes, antagonists, two receptors (IL-1 R I and IL-1 R II) and the IL-1 receptor accessory protein. The IL-1 R II is part of the antagonistic IL-1 mechanism. It is also known as decoy receptor and is a non signaling molecule which functions by capturing IL-1 and preventing it from interacting with the signalling IL-1 R I. The decoy IL-1 R II can after binding to IL-1 also recruit the IL-1 receptor accessory protein and thus inhibit by coreceptor competition. Further a soluble form of IL-1 R II exists which is shed, a process in which matrix metalloproteases have been found to play a role, by various cells including monocytes, polymorphonuclear cells, B cells and fibroblasts. Mouse IgG1
Pathways Signalisation NF-kappaB
Indications d'application It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50. Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one
Restrictions For Research Use only
Buffer PBS, containing 0.02 % sodium azide and 0.1 % bovine serum albumin.
Agent conservateur Sodium azide
Précaution d'utilisation This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock 4 °C
Stockage commentaire Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.
Date de péremption 12 months
Produit citée dans: Müller, Peri, Doni, Perruchoud, Landmann, Pasqualini, Mantovani: "High circulating levels of the IL-1 type II decoy receptor in critically ill patients with sepsis: association of high decoy receptor levels with glucocorticoid administration." dans: Journal of leukocyte biology, Vol. 72, Issue 4, pp. 643-9, 2002 (PubMed).

Penton-Rol, Orlando, Polentarutti, Bernasconi, Muzio, Introna, Mantovani et al.: "Bacterial lipopolysaccharide causes rapid shedding, followed by inhibition of mRNA expression, of the IL-1 type II receptor, with concomitant up-regulation of the type I receptor and induction of ..." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 162, Issue 5, pp. 2931-8, 1999 (PubMed).

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