IL1R2 anticorps

N° du produit ABIN2192218

Détail du produit anti-IL1R2 anticorps

Antigène: IL1R2 (Interleukin 1 Receptor, Type II (IL1R2))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp IL1R2 est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunoassay (IA)

Stérilité: 0.2 μm filtered

Clone: 8-5

Information d'application

Indications d'application: It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50. Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one

Restrictions: For Research Use only

Stockage

Buffer: PBS, containing 0.02 % sodium azide and 0.1 % bovine serum albumin.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.

Date de péremption: 12 months

Références pour anticorps anti-IL1R2 (ABIN2192218)

Müller, Peri, Doni, Perruchoud, Landmann, Pasqualini, Mantovani: "High circulating levels of the IL-1 type II decoy receptor in critically ill patients with sepsis: association of high decoy receptor levels with glucocorticoid administration." dans: Journal of leukocyte biology, Vol. 72, Issue 4, pp. 643-9, (2002) (PubMed).

Penton-Rol, Orlando, Polentarutti, Bernasconi, Muzio, Introna, Mantovani et al.: "Bacterial lipopolysaccharide causes rapid shedding, followed by inhibition of mRNA expression, of the IL-1 type II receptor, with concomitant up-regulation of the type I receptor and induction of ..." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 162, Issue 5, pp. 2931-8, (1999) (PubMed).

Détails sur IL1R2

Antigène: IL1R2 (Interleukin 1 Receptor, Type II (IL1R2))

Abstract: IL1R2 Produits

Synonymes: anticorps CD121b, anticorps CDw121b, anticorps IL-1R-2, anticorps IL-1RT-2, anticorps IL-1RT2, anticorps IL1R2c, anticorps IL1RB, anticorps Il1r-2, anticorps IL-1R2, anticorps interleukin 1 receptor type 2, anticorps interleukin 1 receptor, type II, anticorps interleukin-like, anticorps IL1R2, anticorps Il1r2, anticorps KK34

Sujet: The antibody reacts specificly with Human IL-1 R II. The IL-1 system includes two agonists (IL-1alpha and IL-1beta), converting enzymes, antagonists, two receptors (IL-1 R I and IL-1 R II) and the IL-1 receptor accessory protein. The IL-1 R II is part of the antagonistic IL-1 mechanism. It is also known as decoy receptor and is a non signaling molecule which functions by capturing IL-1 and preventing it from interacting with the signalling IL-1 R I. The decoy IL-1 R II can after binding to IL-1 also recruit the IL-1 receptor accessory protein and thus inhibit by coreceptor competition. Further a soluble form of IL-1 R II exists which is shed, a process in which matrix metalloproteases have been found to play a role, by various cells including monocytes, polymorphonuclear cells, B cells and fibroblasts. Mouse IgG1

Pathways: Signalisation NF-kappaB