MMP12 anticorps (Matrix Metallopeptidase 12 (Macrophage Elastase))

Details for Product anti-MMP12 Antibody No. ABIN223237
Antigène
  • MMP12
  • AV378681
  • Mmel
  • Mme
  • HME
  • ME
  • MME
  • MMP-12
  • matrix metallopeptidase 12
  • MMP12
  • Mmp12
Reactivité
Humain, Souris
169
55
50
7
2
2
1
Hôte
Lapin
182
16
5
3
3
Clonalité
Polyclonal
Conjugué
Cet anticorp MMP12 est non-conjugé
23
15
7
4
4
4
4
4
4
3
3
3
1
1
1
1
1
Application
Western Blotting (WB)
166
70
70
18
18
17
13
11
11
2
2
2
1
Options
Immunogène Synthetic peptide surrounding amino acid 460 of human MMP-12
Isotype IgG
Specificité The antibody recognizes a ~50 kDa band from samples of human origin.
Reactivity to other species has not been tested.
Purification Affinity purified
Plasmids, Primers & others Plasmids, Primers & others MMP12 products on genomics-online (e.g. as negative or positive controls)
Antigène
Autre désignation MMP-12 (MMP12 Antibody Extrait)
Sujet The matrix metalloproteinases (MMP) are a family of peptidase enzymes responsible for the degradation of extracellular matrix components, including collagen, gelatin, fibronectin, laminin and proteoglycan. Transcription of MMP genes is differentially activated by phorbol ester, lipopolysaccharide (LPS) or staphylococcal enterotoxin B (SEB). MMP catalysis requires both calcium and zinc. MMP-12 (also designated macrophage metalloelastase) is produced in alveolar macrophages and degrades elastin. MMP-12 may contribute to elastin degradation occurring in granulomatous skin diseases and may also participate in macrophage migration throμgh the epidermal and vascular basement membranes in inflammatory disorders.
Synonyms: HME, MME ,Matrix metalloproteinase
ID gène 4321
NCBI Accession NP_002417
Indications d'application Western blotting (1-4 μg/mL). However, the optimal concentrations should be determined individually.The antibody recognizes a ~50 kDa band from samples of human origin. Reactivity to other species has not been tested. Jurkat cell lysate can be used as a positive control.
Restrictions For Research Use only
Format Liquid
Concentration 0.2 mg/mL
Buffer 100 μg (0.2 mg/mL) protein A purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 50 % glycerol, 1 % BSA, and 0.02 % thimerosal.
Agent conservateur Thimerosal (Merthiolate)
Précaution d'utilisation This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation The antibody solution should be gently mixed before use.
Stock -20 °C
Stockage commentaire For long-term storage, aliquot and freeze at -70 °C.
Date de péremption 12 months
Produit citée dans: Hountis, Ikonomidis, Stamatelopoulos, Douzinas: "Compression of the right atrium due to coexistence of diaphragmatic eventration and Chilaiditi's syndrome." dans: The Thoracic and cardiovascular surgeon, Vol. 56, Issue 6, pp. 365-7, 2008 (PubMed).

Background publications Ikonomidis, Jones, Barbour, Stroud, Clark, Kaplan, Zeeshan, Bavaria, Gorman, Spinale, Gorman: "Expression of matrix metalloproteinases and endogenous inhibitors within ascending aortic aneurysms of patients with bicuspid or tricuspid aortic valves." dans: The Journal of thoracic and cardiovascular surgery, Vol. 133, Issue 4, pp. 1028-36, 2007 (PubMed).

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