Cytochrome P450, Family 19, Subfamily A, Polypeptide 1 (CYP19A1) anticorps

Détails pour le produit réf. ABIN223293
Antigène
  • ARO
  • ARO1
  • CPV1
  • CYAR
  • CYP19
  • CYPXIX
  • P-450AROM
  • Aromatase
  • Cyp19
  • Cyp19a
  • p450arom
  • P450 arom
  • aro
  • cyp19
  • cyp19a
  • p450arom-A
  • P450AROM
  • Ar
  • ArKO
  • Int-5
  • Int5
  • CYP19P1
  • CYP19A1
  • CYP19a1
  • P450aromA
  • ar1
  • cypXIX
  • etID309862.18
  • zgc:136541
  • cyp19a1
  • cytochrome P450 family 19 subfamily A member 1
  • cytochrome P450, family 19, subfamily a, polypeptide 1
  • cytochrome P450 family 19 subfamily A member 1 L homeolog
  • aromatase
  • cytochrome P450 aromatase
  • cytochrome P450, family 19, subfamily A, polypeptide 1
  • cytochrome P450 19A1
  • cytochrome P450, family 17, subfamily A, polypeptide 1
  • cytochrome P450, family 19
  • cytochrome P450, family 19, subfamily A, polypeptide 1a
  • cytochrome P450 19A1-like
  • CYP19A1
  • Cyp19a1
  • cyp19a1.L
  • SAV_2383
  • pfcyp19b-tstr
  • CYP19
  • cyp19a1a
  • LOC101174651
Reactivité
Poulet, Boeuf (Vache), Cheval, Humain, Souris, Porc, Lapin, Rat (Rattus)
165
86
60
7
5
4
4
3
3
3
3
2
2
2
2
1
1
1
Hôte
Lapin
133
24
21
Clonalité
Polyclonal
Conjugué
Inconjugué
7
4
4
4
4
4
4
4
4
2
2
2
2
2
2
1
1
1
1
1
Application
Immunohistochemistry (IHC), Western Blotting (WB)
127
60
53
33
26
19
14
7
7
6
4
4
Options
Immunogène Synthetic peptide surrounding amino acid 385 of human Aromatase
Blocking Peptide Blocking peptide for this product available: ABIN412600
Isotype IgG
Specificité A 55 kDa band can be detected, corresponding to the expected molecular weight of Aromatase.
Antigène
Autre désignation Aromatase (CYP19A1 Antibody Extrait)
Sujet Aromatase is a key enzyme in steroidogenesis and plays an important role in sexual differentiation, fertility, and carcinogenesis. Many environmental chemicals may influence aromatase activity and thereby disrupt endocrine function.
Synonyms: 25147 , Cyp19a1, Aromatase , Cyp19 , p450arom , ARO1, ARO 1, CPV, CYP19A1 , MGC104309
ID gène 1588
UniProt P11511
Pathways Metabolism of Steroid Hormones and Vitamin D, Steroid Hormone Biosynthesis, C21-Steroid Hormone Metabolic Process, Carbohydrate Homeostasis
Indications d'application Western blotting (0.5-4 μg/mL), Immunohistochemistry (10-20 μg/mL). However, the optimal concentrations should be determined individually. Jurkat cell lysate can be used as a positive control. The antibody should recognize aromatase in samples from human, mouse, rat, bovine, porcine, pig, sheep, rabbit, horse and chicken origins. A 55 kDa band can be detected, corresponding to the expected molecular weight of Aromatase. An additional 35 kDa band (believe to be the cleavage product of Aromatase) can also be detected in Jurkat cells.
Restrictions For Research Use only
Format Liquid
Concentration 0.2 mg/mL
Buffer 100 μg (0.2 mg/mL) affinity purified rabbit anti-Aromatase polyclonal antibody in phosphate-buffered saline (PBS) containing 30 % glycerol, 0.5 % BSA, and 0.01 % thimerosal.
Agent conservateur Thimerosal (Merthiolate)
Précaution d'utilisation This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation The antibody solution should be gently mixed before use.
Stock -20 °C
Stockage commentaire For long-term storage, aliquot and freeze at -70 °C.
Date de péremption 12 months
Images (Fournisseur)
Western Blotting (WB) image for anti-Cytochrome P450, Family 19, Subfamily A, Polypeptide 1 (CYP19A1) antibody (ABIN223293) Western blot analysis of Aromatase in human brain cell lysate.
Produit citée dans: El Hajj Chehadeh, Dreumont, Willekens, Canabady-Rochelle, Jeannesson, Alberto, Daval, Guéant, Leininger-Muller: "Early methyl donor deficiency alters cAMP signaling pathway and neurosteroidogenesis in the cerebellum of female rat pups." dans: American journal of physiology. Endocrinology and metabolism, Vol. 307, Issue 11, pp. E1009-19, 2014 (PubMed).

Yonezawa, Higashi, Yoshioka, Mutoh: "Distribution of aromatase and sex steroid receptors in the baculum during the rat life cycle: effects of estrogen during the early development of the baculum." dans: Biology of reproduction, Vol. 85, Issue 1, pp. 105-12, 2011 (PubMed).

Bukulmez, Hardy, Carr, Word, Mendelson: "Inflammatory status influences aromatase and steroid receptor expression in endometriosis." dans: Endocrinology, Vol. 149, Issue 3, pp. 1190-204, 2008 (PubMed).

Hirayama, Sawai, Moriyasu, Hirayama, Goto, Kaneko, Miyamoto, Ushizawa, Takahashi, Minamihashi: "Excess estrogen sulfoconjugation as the possible cause for a poor sign of parturition in pregnant cows carrying somatic cell clone fetuses." dans: Reproduction (Cambridge, England), Vol. 136, Issue 5, pp. 639-47, 2008 (PubMed).

Sun, Yan, Jacobson, Jiang, Carroll, Huang: "Contribution of epoxyeicosatrienoic acids to flow-induced dilation in arteries of male ERalpha knockout mice: role of aromatase." dans: American journal of physiology. Regulatory, integrative and comparative physiology, Vol. 293, Issue 3, pp. R1239-46, 2007 (PubMed).

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