IL1B anticorps (Interleukin 1, beta)

Details for Product anti-IL1B Antibody No. ABIN223538
Antigène
  • il1-b
  • zgc:111873
  • IL-1beta
  • Il-1b
  • IL1B
  • IL-1
  • IL1-BETA
  • IL1F2
  • IL-1BETA
  • IL1beta
  • IL-1B
  • interleukin 1, beta
  • interleukin 1 beta
  • il1b
  • Il1b
  • IL1B
Reactivité
Souris
352
166
121
37
23
21
16
14
13
11
9
9
8
4
4
2
2
1
Hôte
Lapin
421
174
15
8
8
8
2
2
Clonalité
Polyclonal
Conjugué
Cet anticorp IL1B est non-conjugé
84
35
23
12
6
4
4
4
3
3
3
3
3
3
3
1
1
1
1
1
1
1
Application
Neutralization (Neut), Western Blotting (WB)
444
340
194
67
65
55
43
36
33
31
31
23
22
16
14
5
4
4
3
3
3
3
2
2
2
1
1
1
1
Options
Immunogène E. coli expressed murine IL-1beta
Isotype IgG
Purification Affinity purified
Plasmids, Primers & others Plasmids, Primers & others IL1B products on genomics-online (e.g. as negative or positive controls)
Antigène
Autre désignation IL-1b (IL1B Antibody Extrait)
Sujet IL-1beta is a proinflammatory cytokine produced in a variety of cells including monocytes, tissue macrophages, keratinocytes and other epithelial cells. Both IL-1alpha and IL-1beta binds to the same receptor and has similar if not identical biological properties. These cytokines have a broad range of activities including, stimulation of thymocyte proliferation, by inducing IL-2 release, B-cell maturation and proliferation, mitogenic FGF-like activity and the ability to stimulate the release of prostaglandin and collagenase from synovial cells. However, whereas IL-1beta is a secreted cytokine, IL-1alpha is predominantly a cell-associated cytokine. Recombinant murine IL-1beta is a 17.5 kDa protein containing 153 amino acid residues.
Synonyms: IL-1 beta, IL1 beta, IL 1 beta, Interluekin-1 beta, Interluekin 1 beta, interluekin
ID gène 52667
Pathways Signalisation NF-kappaB, Interferon-gamma Pathway, Negative Regulation of Hormone Secretion, Cellular Response to Molecule of Bacterial Origin, Carbohydrate Homeostasis, Glycosaminoglycan Metabolic Process, Myometrial Relaxation and Contraction, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Autophagy, Cancer Immune Checkpoints
Indications d'application Western blot analysis (0.5-4 μg/mL). Recombinant murine IL-1β can be used as a positive control. Per researcher's feedback, the antibody can also be used in neutralization studies. However, the optimal conditions should be determined individually.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer 100 μg (0.5 mg/mL) affinity purified rabbit anti-murine IL-1β polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30 % glycerol, 0.5 %BSA and 0.01 % thimerosal.
Agent conservateur Thimerosal (Merthiolate)
Précaution d'utilisation This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation The antibody solution should be gently mixed before use.
Stock -20 °C
Stockage commentaire For long-term storage, aliquot and freeze at -70 °C.
Date de péremption 12 months
Images (Fournisseur)
 image for anti-Interleukin 1, beta (IL1B) antibody (ABIN223538) anti-Interleukin 1, beta (IL1B) antibody
Produit citée dans: Wang, Viollet, Terkeltaub, Liu-Bryan: "AMP-activated protein kinase suppresses urate crystal-induced inflammation and transduces colchicine effects in macrophages." dans: Annals of the rheumatic diseases, 2014 (PubMed).

Zhang, Xu, Ma, Wu, Wang, Zhou, Han: "Gene deletion of Gabarap enhances Nlrp3 inflammasome-dependent inflammatory responses." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 190, Issue 7, pp. 3517-24, 2013 (PubMed).

Martin, Shaw, Liu, Steiger, Harper: "MSU crystal-recruited non-inflammatory monocytes differentiate into M1-like pro-inflammatory macrophages in a peritoneal murine model of gout." dans: Arthritis and rheumatism, 2011 (PubMed).

Martin, Shaw, Liu, Steiger, Harper: "Monosodium urate monohydrate crystal-recruited noninflammatory monocytes differentiate into M1-like proinflammatory macrophages in a peritoneal murine model of gout." dans: Arthritis and rheumatism, Vol. 63, Issue 5, pp. 1322-32, 2011 (PubMed).

Sozen, Tsuchiyama, Hasegawa, Suzuki, Jadhav, Nishizawa, Zhang: "Role of interleukin-1beta in early brain injury after subarachnoid hemorrhage in mice." dans: Stroke; a journal of cerebral circulation, Vol. 40, Issue 7, pp. 2519-25, 2009 (PubMed).

Scott, Ma, Viriyakosol, Terkeltaub, Liu-Bryan: "Engagement of CD14 mediates the inflammatory potential of monosodium urate crystals." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 177, Issue 9, pp. 6370-8, 2006 (PubMed).

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