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NFYA anticorps (N-Term)

NFYA Reactivité: Humain GS, WB Hôte: Lapin Polyclonal unconjugated
Pubmed (4 références)
N° du produit ABIN233754
$482.90
Plus frais de port $45.00 et $20.00 pour carboglace
100 μL
Destination: Etats-Unis
Envoi sous 1 à 2 jours ouvrables
  • Antigène Voir toutes NFYA Anticorps
    NFYA (Nuclear Transcription Factor Y, alpha (NFYA))
    Épitope
    • 8
    • 4
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivité
    • 26
    • 20
    • 18
    • 6
    • 5
    • 4
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 25
    • 1
    Lapin
    Clonalité
    • 25
    • 1
    Polyclonal
    Conjugué
    • 19
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp NFYA est non-conjugé
    Application
    • 19
    • 12
    • 10
    • 8
    • 7
    • 5
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    Gel Shift (GS), Western Blotting (WB)
    Attributs du produit
    Concentration Definition: by Refractometry
    Purification
    Antiserum
    Immunogène
    NF-Y (A subunit specific) peptide corresponding to a region near the of the human protein conjugated to Keyhole Limpet Hemocyanin (KLH).
  • Indications d'application
    Anti-NF-Y (A subunit) Antibody was assayed by immunoblot and found to be reactive against NF-Y (A subunit specific) at a dilution of 1:6,000 followed by reaction with Peroxidase conjugated Affinity Purified anti-Rabbit IgG [H&L] Goat).  Anti-NF-Y (A subunit specific) is suitable for the detection by immunoblot of human and mouse NF-Y.  Negligible reactivity was observed against the B subunit of NF-Y.   Anti-NF-Y (A subunit) Antibody was also tested in a gel supershift assay and found to be reactive against NF-Y using 1.0 to 2.0 µl per assay. Specific conditions should be optimized by user.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    90 mg/mL
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
  • Manni, Caretti, Artuso, Gurtner, Emiliozzi, Sacchi, Mantovani, Piaggio: "Posttranslational regulation of NF-YA modulates NF-Y transcriptional activity." dans: Molecular biology of the cell, Vol. 19, Issue 12, pp. 5203-13, (2008) (PubMed).

    Gurtner, Fuschi, Magi, Colussi, Gaetano, Dobbelstein, Sacchi, Piaggio: "NF-Y dependent epigenetic modifications discriminate between proliferating and postmitotic tissue." dans: PLoS ONE, Vol. 3, Issue 4, pp. e2047, (2008) (PubMed).

    Bennett, Seo, Datta, Shin, Osborne: "Selective binding of sterol regulatory element-binding protein isoforms and co-regulatory proteins to promoters for lipid metabolic genes in liver." dans: The Journal of biological chemistry, Vol. 283, Issue 23, pp. 15628-37, (2008) (PubMed).

    Huang, Wu, Choo: "Transcriptional modulation of the pre-implantation embryo-specific Rnf35 gene by the Y-box protein NF-Y/CBF." dans: The Biochemical journal, Vol. 387, Issue Pt 2, pp. 367-75, (2005) (PubMed).

  • Antigène
    NFYA (Nuclear Transcription Factor Y, alpha (NFYA))
    Abstract
    NFYA Produits
    Synonymes
    wu:fb16e03, ik:tdsubc_2b6, xx:tdsubc_2b6, NFYA, CBF-A, CBF-B, HAP2, NF-YA, AA407810, Cbf-b, SEZ-10, SEZ10, nuclear transcription factor Y, alpha, nuclear transcription factor Y subunit alpha, nuclear transcription factor-Y alpha, nfya, NFYA, Nfya
    Sujet
    Nuclear transcription factor Y subunit alpha is a protein that in humans is encoded by the NFYA gene. The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds to CCAAT motifs in the promoter regions in a variety of genes. Subunit A associates with a tight dimer composed of the B and C subunits, resulting in a trimer that binds to DNA with high specificity and affinity. The sequence specific interactions of the complex are made by the A subunit, suggesting a role as the regulatory subunit. In addition, there is evidence of post-transcriptional regulation in this gene product, either by protein degradation or control of translation. Further regulation is represented by alternative splicing in the glutamine-rich activation domain, with clear tissue-specific preferences for the two isoforms. Anti-NF-Y is ideal for investigators involved in transcription factor research.
    Synonyms: Nuclear transcription factor Y subunit alpha Nuclear transcription factor Y subunit A NF-YA CAAT box DNA-binding protein subunit A
    ID gène
    4800
    UniProt
    P23511
    Pathways
    Regulation of Lipid Metabolism by PPARalpha
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