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CAMK4 anticorps (AA 305-323)

CAMK4 Reactivité: Humain ELISA, WB Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN233765
$482.90
Plus shipping costs $45.00
100 μL
Destination: Etats-Unis
Envoi sous 1 à 2 jours ouvrables
  • Antigène Voir toutes CAMK4 Anticorps
    CAMK4 (Calcium/calmodulin-Dependent Protein Kinase IV (CAMK4))
    Épitope
    • 24
    • 19
    • 11
    • 8
    • 7
    • 6
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 305-323
    Reactivité
    • 70
    • 63
    • 44
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 75
    • 13
    Lapin
    Clonalité
    • 68
    • 20
    Polyclonal
    Conjugué
    • 53
    • 5
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp CAMK4 est non-conjugé
    Application
    • 66
    • 38
    • 24
    • 21
    • 14
    • 12
    • 5
    • 5
    • 4
    • 3
    • 1
    • 1
    • 1
    ELISA, Western Blotting (WB)
     Réactivité croisée
    Souris, Rat (Rattus), Chien, Mouton, Chimpanzé
    Attributs du produit
    Concentration Definition: by Refractometry
    Purification
    Antiserum
    Immunogène
    This antiserum was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids 305-323 of Human CaM Kinase IV protein.
  • Indications d'application
    This antiserum has been tested for use in ELISA and western blot.  Specific conditions for reactivity should be optimized by the end user. Expect a band ~ 52 kDa in size corresponding to CaM Kinase IV by western blotting in the appropriate cell lysate or extract.
    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Restore with deionized water (or equivalent)
    Concentration
    70 mg/mL
    Buffer
    0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C
  • Antigène
    CAMK4 (Calcium/calmodulin-Dependent Protein Kinase IV (CAMK4))
    Autre désignation
    CaM Kinase IV (CAMK4 Produits)
    Synonymes
    CaMK IV, CaMK-GR, IV, caMK, CAMK4, A430110E23Rik, AI666733, CaMKIV, CaMKIV/Gr, D18Bwg0362e, Ccdpk, RATCCDPK, camk4-A, wu:fj42a03, zgc:110275, calcium/calmodulin dependent protein kinase IV, calcium/calmodulin-dependent protein kinase IV, calcium/calmodulin-dependent protein kinase IV L homeolog, CAMK4, Camk4, camk4.L, camk4
    Sujet
    CaM Kinase IV (also known as CAM kinase-GR and CaMK IV) is a calcium/ calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade. This kinase may be involved in the transcriptional regulation of microtubule dynamics. In vitro, CaMK IV phosphorylates CREB1, CREBBP, PRM2, MEF2A, MEF2D and STMN1/OP18.   CaMK IV may also be involved in spermatogenesis and may play a role in the consolidation/ retention of hippocampus-dependent long-term memory.  CaMK IV must be phosphorylated to be maximally active and is phosphorylated by CAMKK1 or CAMKK2.  In addition autophosphorylation of the N-terminus is required for full activation.  Autophosphorylation of Ser-336 allows the kinase to switch to a Ca(2+)/calmodulin-independent state.  Most likely the kinase is inactivated by the serine/ threonine protein phosphatase 2A.  CaMK IV is a monomer that is located within the cytoplasm and nucleus and substantial localization occurs in certain neuronal nuclei. In spermatids CaMK IV is associated with chromatin and the nuclear matrix.  CaMK IV is also specifically expressed in epithelial ovarian cancer tissue.
    Synonyms: CAM kinase 4 antibody, CAM kinase GR antibody, CAM kinase IV antibody, CaMK4 antibody, CaMKGR antibody, Brain Ca(2+) calmodulin dependent protein kinase type IV antibody, Calcium / calmodulin dependent protein kinase type 4 catalytic chain antibody
    ID gène
    25050, 60392502
    UniProt
    P13234
    Pathways
    EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Production of Molecular Mediator of Immune Response, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma
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