Tel:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@anticorps-enligne.fr

FBXO4 anticorps (N-Term)

FBXO4 Reactivité: Humain WB Hôte: Lapin Polyclonal unconjugated
Pubmed (4 références)
N° du produit ABIN233769
$658.50
Plus frais de port $45.00 et $20.00 pour carboglace
100 μL
Destination: Etats-Unis
Envoi sous 1 à 2 jours ouvrables
  • Antigène Voir toutes FBXO4 Anticorps
    FBXO4 (F-Box Protein 4 (FBXO4))
    Épitope
    • 15
    • 9
    • 8
    • 8
    • 5
    • 4
    • 4
    • 2
    • 1
    • 1
    • 1
    N-Term
    Reactivité
    • 58
    • 19
    • 19
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 46
    • 8
    • 4
    Lapin
    Clonalité
    • 56
    • 2
    Polyclonal
    Conjugué
    • 23
    • 5
    • 5
    • 5
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp FBXO4 est non-conjugé
    Application
    • 32
    • 30
    • 13
    • 5
    • 3
    • 3
    • 2
    • 1
    Western Blotting (WB)
     Réactivité croisée
    Souris
    Attributs du produit
    Concentration Definition: by Refractometry
    Purification
    Antiserum
    Immunogène
    This whole rabbit serum was prepared by repeated immunizations with a synthetic peptide derived from sequences unique to the of FBX4 and conserved between the human and murine proteins (see link below for the full-length sequence of the mouse gene product).
  • Indications d'application
    This antiserum has been tested for use in western blotting and immunocytochemistry.  Specific conditions for reactivity should be optimized by the end user.  Expect a band approximately 44 kDa in size by western blotting in the appropriate cell lysate or extract.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    85 mg/mL
    Buffer
    0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
  • Gong, Zack, Morris, Lin, Hukkelhoven, Raheja, Tan, Turcan, Veeriah, Meng, Viale, Schumacher, Palmedo, Beroukhim, Chan: "Pan-cancer genetic analysis identifies PARK2 as a master regulator of G1/S cyclins." dans: Nature genetics, Vol. 46, Issue 6, pp. 588-94, (2014) (PubMed).

    Barbash, Lee, Diehl: "Phosphorylation-dependent regulation of SCF(Fbx4) dimerization and activity involves a novel component, 14-3-3ɛ" dans: Oncogene, (2011) (PubMed).

    Pontano, Aggarwal, Barbash, Brown, Bassing, Diehl: "Genotoxic stress-induced cyclin D1 phosphorylation and proteolysis are required for genomic stability." dans: Molecular and cellular biology, Vol. 28, Issue 23, pp. 7245-58, (2008) (PubMed).

    Barbash, Zamfirova, Lin, Chen, Yang, Nakagawa, Lu, Rustgi, Diehl: "Mutations in Fbx4 inhibit dimerization of the SCF(Fbx4) ligase and contribute to cyclin D1 overexpression in human cancer." dans: Cancer cell, Vol. 14, Issue 1, pp. 68-78, (2008) (PubMed).

  • Antigène
    FBXO4 (F-Box Protein 4 (FBXO4))
    Autre désignation
    FBXO4 (FBXO4 Produits)
    Synonymes
    FBX4, 1700096C12Rik, AI851261, AW494535, Fbx4, FBXO4, fbx4, si:dkey-46a10.2, F-box protein 4, F-box protein 4 L homeolog, FBXO4, Fbxo4, fbxo4, fbxo4.L
    Sujet
    Skp/Cullin/F-box (SCF) complexes are part of a large family of E3 ubiquitin ligases in which F-box proteins determine substrate specificity.  Substrate selection by F-box proteins may also be aided by accessory cofactors.  The F-box only protein 4, FBX4, interacts via its F-box with SKP1 and CUL1 to form SCFFBX4 ubiquitin ligase.  The activity of the SCFFBX4 complex can be regulated by aB crystallin, a small heat shock protein which serves as a specificity cofactor for FBX4 dependent ubiquitination.  FBX4 together with aB crystallin (SCFFBX4-aB crystallin) promotes the ubiquitination of cyclin D1 phosphorylated at Thr-286.  In addition, the    SCFFBX4-aB crystallin ubiquitin ligase has been implicated in the ubiquitination of unknown substrates in desmin-related myopathy.  SCFFBX4, in the absence of aB crystallin, also ubiquitinates the telomeric protein PIN2/TRF1.
    Synonyms: F box protein 4 antibody, F box protein Fbx4 antibody, FBX4 antibody, FBXO 4 antibody, FLJ10141 antibody
    ID gène
    106052, 256665259
    UniProt
    Q8CHQ0
Vous êtes ici:
Support technique