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Cullin 3 anticorps (N-Term)

CUL3 Reactivité: Humain IP, WB Hôte: Lapin Polyclonal unconjugated
Pubmed (4 références)
N° du produit ABIN233772
$658.50
Plus frais de port $45.00 et $20.00 pour carboglace
100 μL
Destination: Etats-Unis
Envoi sous 1 à 2 jours ouvrables
  • Antigène Voir toutes Cullin 3 (CUL3) Anticorps
    Cullin 3 (CUL3)
    Épitope
    • 15
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-12, N-Term
    Reactivité
    • 53
    • 25
    • 21
    • 6
    • 5
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    Humain
    Hôte
    • 50
    • 2
    • 1
    Lapin
    Clonalité
    • 49
    • 4
    Polyclonal
    Conjugué
    • 32
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp Cullin 3 est non-conjugé
    Application
    • 26
    • 16
    • 13
    • 13
    • 13
    • 7
    • 5
    • 5
    • 3
    • 2
    • 1
    • 1
    Immunoprecipitation (IP), Western Blotting (WB)
    Attributs du produit
    Concentration Definition: by Refractometry
    Purification
    Antiserum
    Immunogène
    This antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids 1-12 of Human Cul3 coupled to KLH.
  • Indications d'application
    This antibody reacts with human Cul3 by western blot and immunoprecipitation.  The antibody immunoprecipitates in vitro translated product and protein from cell lysates (using HeLa or NIH-3T3).  An 88.9 kDa band corresponding to human Cul3 is detected.  Most cell lines expressing Cul3 can be used as a positive control.  Researchers should determine optimal titers for other applications.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    85 mg/mL
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
  • Shiraishi, Zhou, Aoki, Sato, Chiba, Tanaka, Yoshida, Nabeshima, Nabeshima, Tamura: "TBP-interacting protein 120B (TIP120B)/cullin-associated and neddylation-dissociated 2 (CAND2) inhibits SCF-dependent ubiquitination of myogenin and accelerates myogenic differentiation." dans: The Journal of biological chemistry, Vol. 282, Issue 12, pp. 9017-28, (2007) (PubMed).

    Furukawa, He, Borchers, Xiong: "Targeting of protein ubiquitination by BTB-Cullin 3-Roc1 ubiquitin ligases." dans: Nature cell biology, Vol. 5, Issue 11, pp. 1001-7, (2003) (PubMed).

    Michel, Xiong: "Human CUL-1, but not other cullin family members, selectively interacts with SKP1 to form a complex with SKP2 and cyclin A." dans: Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research, Vol. 9, Issue 6, pp. 435-49, (1998) (PubMed).

    Kipreos, Lander, Wing, He, Hedgecock: "cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family." dans: Cell, Vol. 85, Issue 6, pp. 829-39, (1996) (PubMed).

  • Antigène
    Cullin 3 (CUL3)
    Autre désignation
    Cul3 (CUL3 Produits)
    Synonymes
    CUL-3, Cullin-3, CUL-3-A, Cullin-3-A, cul3, cul3a, CUL-3-B, Cullin-3-B, cul3b, wu:fc37e01, CUL3, ATCUL3, ATCUL3A, CUL3A, T24P13.25, cullin 3, cullin 3A, PHA2E, AI467304, AW146203, mKIAA0617, cullin 3, cullin 3 L homeolog, cullin 3 S homeolog, cullin-3, Cullin-3 (CUL-3), cullin 3a, CULlin, CUL3, cul3, cul3.L, cul3.S, PTRG_11586, Smp_117580, cul3a, Cul3, cul-3
    Sujet
    Cullins assemble a potentially large number of ubiquitin ligases by binding to the RING protein ROC1 to catalyse polyubiquitination, as well as binding to various specificity factors to recruit substrates.  Cullin 3 is an essential component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, cul3 serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits.  Cul3 may also contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme.  Unlike Cul1 and Cul2, Cul3 seems not to be a part of the SCF complex consisting of CUL1, RBX1, SKP1 and SKP2.  Cul3 also interacts with RNF7 and is part of a complex with TIP120A/CAND1, Cyclin E and RBX1.
    Synonyms: Cullin3 antibody, KIAA0617 antibody
    ID gène
    8452, 4503165
    UniProt
    Q13618
    Pathways
    M Phase
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