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DDB1 anticorps (Internal Region)

DDB1 Reactivité: Humain IP, WB Hôte: Lapin Polyclonal unconjugated
Pubmed (2 références)
N° du produit ABIN233778
$658.50
Plus frais de port $45.00 et $20.00 pour carboglace
100 μL
Destination: Etats-Unis
Envoi sous 1 à 2 jours ouvrables
  • Antigène Voir toutes DDB1 Anticorps
    DDB1 (Damage Specific DNA Binding Protein 1 (DDB1))
    Épitope
    • 13
    • 5
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 198-213, Internal Region
    Reactivité
    • 49
    • 19
    • 17
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 33
    • 8
    • 8
    Lapin
    Clonalité
    • 40
    • 8
    Polyclonal
    Conjugué
    • 32
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp DDB1 est non-conjugé
    Application
    • 36
    • 24
    • 12
    • 10
    • 10
    • 8
    • 6
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Immunoprecipitation (IP), Western Blotting (WB)
    Attributs du produit
    Concentration Definition: by Refractometry
    Purification
    Antiserum
    Immunogène
    This antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids 198-213 of Human DDB1 coupled to KLH.
  • Indications d'application
    This antibody reacts with human and mouse  DDB1 by western blot and immunoprecipitation.  The antibody immunoprecipitates in vitro translated protein and protein from cell lysates (using HeLa, NIH-3T3, and others).  Coimmunoprecipitation of related proteins has not been tested.  A 127.0 kDa band corresponding to human DDB1 is detected.  Most cell lines expressing DDB1 can be used as a positive control.  Researchers should determine optimal titers for other applications.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    85 mg/mL
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
  • Shiyanov, Nag, Raychaudhuri: "Cullin 4A associates with the UV-damaged DNA-binding protein DDB." dans: The Journal of biological chemistry, Vol. 274, Issue 50, pp. 35309-12, (2000) (PubMed).

    Shiyanov, Hayes, Donepudi, Nichols, Linn, Slagle, Raychaudhuri: "The naturally occurring mutants of DDB are impaired in stimulating nuclear import of the p125 subunit and E2F1-activated transcription." dans: Molecular and cellular biology, Vol. 19, Issue 7, pp. 4935-43, (1999) (PubMed).

  • Antigène
    DDB1 (Damage Specific DNA Binding Protein 1 (DDB1))
    Autre désignation
    p127-DDB1 (DDB1 Produits)
    Synonymes
    DDBA, UV-DDB1, XAP1, XPCE, XPE, XPE-BF, DDB1, xpe, ddba, xap1, xpce, xpe-bf, uv-ddb1, ddb1, 127kDa, AA408517, p127-Ddb1, damage specific DNA binding protein 1, damage-specific DNA binding protein 1, 127kDa, DNA damage-binding protein 1, damage-specific DNA binding protein 1, DDB1, ddb1, LOC100187356, Ddb1, ddb-1
    Sujet
    DDB1 is also known as damage-specific DNA binding protein 1, DDB p127 subunit, DDBa, UV-damaged DNA-binding protein 1, UV-DDB 1, Xeroderma pigmentosum group E complementing protein, XPCe, X-associated protein 1 and XAP-1.  The DDB1 gene encodes the large subunit (p127) of DNA damage-binding protein, which is a heterodimer, composed of a large and a small subunit (p48 DDB2). This nuclear protein functions in nucleotide-excision repair resulting from UV-damaged DNA by binding to pyrimidine dimers.  Its defective activity causes the repair defect in the patients with xeroderma pigmentosum complementation group E (XPE). XP-E is a rare human autosomal recessive disease characterized by solar sensitivity, high predisposition for developing cancers on areas exposed to sunlight and, in some cases, neurological abnormalities.  However, it remains for mutation analysis to demonstrate whether the defect in XPE patients is in this gene or the gene encoding the small subunit.  In addition, Best vitelliform mascular dystrophy is mapped to the same region as this gene on 11q, but no sequence alternations of this gene are demonstrated in Best disease patients.
    Synonyms: Damage specific DNA binding protein 1 antibody, DDB 1 antibody, DDB p127 subunit antibody, DDBa antibody, DNA damage binding protein 1 antibody, UV damaged DNA binding factor antibody
    ID gène
    1642, 148529014
    UniProt
    Q16531
    Pathways
    Réparation de l'ADN
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