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DDB2 anticorps (C-Term)

DDB2 Reactivité: Humain IP, WB Hôte: Lapin Polyclonal unconjugated
Pubmed (3 références)
N° du produit ABIN233779
$658.50
Plus frais de port $45.00 et $20.00 pour carboglace
100 μL
Destination: Etats-Unis
Envoi sous 1 à 2 jours ouvrables
  • Antigène Voir toutes DDB2 Anticorps
    DDB2 (Damage-Specific DNA Binding Protein 2, 48kDa (DDB2))
    Épitope
    • 6
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 419-427, C-Term
    Reactivité
    • 41
    • 18
    • 14
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 40
    • 3
    Lapin
    Clonalité
    • 30
    • 13
    Polyclonal
    Conjugué
    • 25
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    Cet anticorp DDB2 est non-conjugé
    Application
    • 25
    • 11
    • 6
    • 5
    • 5
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Immunoprecipitation (IP), Western Blotting (WB)
    Attributs du produit
    Concentration Definition: by Refractometry
    Purification
    Antiserum
    Immunogène
    This antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids 419-427 of Human DDB2 coupled to KLH.
  • Indications d'application
    This antibody reacts with human DDB2 by western blot and immunoprecipitation.  The antibody immunoprecipitates in vitro translated protein and protein from cell lysates (using 293T, and others).  Coimmunoprecipitation of related proteins has not been tested.  A 47.8 kDa band corresponding to human DDB2 is detected.  Most cell lines expressing DDB2 can be used as a positive control.  Researchers should determine optimal titers for other applications.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    85 mg/mL
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
  • Abbas, Sivaprasad, Terai, Amador, Pagano, Dutta: "PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex." dans: Genes & development, Vol. 22, Issue 18, pp. 2496-506, (2008) (PubMed).

    Shiyanov, Nag, Raychaudhuri: "Cullin 4A associates with the UV-damaged DNA-binding protein DDB." dans: The Journal of biological chemistry, Vol. 274, Issue 50, pp. 35309-12, (2000) (PubMed).

    Shiyanov, Hayes, Donepudi, Nichols, Linn, Slagle, Raychaudhuri: "The naturally occurring mutants of DDB are impaired in stimulating nuclear import of the p125 subunit and E2F1-activated transcription." dans: Molecular and cellular biology, Vol. 19, Issue 7, pp. 4935-43, (1999) (PubMed).

  • Antigène
    DDB2 (Damage-Specific DNA Binding Protein 2, 48kDa (DDB2))
    Abstract
    DDB2 Produits
    Synonymes
    2610043A19Rik, si:dkey-45f10.3, DDBB, UV-DDB2, damage specific DNA binding protein 2, damage-specific DNA binding protein 2, DDB2, ddb2, Ddb2
    Sujet
    DDB2 is also known as Damage-specific DNA binding protein 2, DDB p48 subunit, DDBb, UV-damaged DNA-binding protein 2 and UV-DDB 2.  The DDB2 gene encodes the small subunit (p48) of DNA damage-binding protein, which is a heterodimer, composed of a large (p127 DDB1) and a small subunit.  The DDB2 subunit appears to be required for DNA binding.  This nuclear protein functions in nucleotide-excision repair resulting from UV-damaged DNA by binding to pyrimidine dimers.  Its defective activity causes the repair defect in the patients with xeroderma pigmentosum complementation group E (XPE).  XP-E is a rare human autosomal recessive disease characterized by solar sensitivity, high predisposition for developing cancers on areas exposed to sunlight and, in some cases, neurological abnormalities.  However, it remains for mutation analysis to demonstrate whether the defect in XPE patients is in this gene or the gene encoding the large subunit.
    Synonyms: damage-specific DNA binding protein 2 antibody, UV-DDB 2 antibody
    ID gène
    1643, 4557515
    UniProt
    Q92466
    Pathways
    Réparation de l'ADN
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