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RIT2 anticorps (C-Term)

RIT2 Reactivité: Humain IP, WB Hôte: Lapin Polyclonal unconjugated
Pubmed (3 références)
N° du produit ABIN233783
$658.50
Plus frais de port $45.00 et $20.00 pour carboglace
100 μL
Destination: Etats-Unis
Envoi sous 1 à 2 jours ouvrables
  • Antigène Voir toutes RIT2 Anticorps
    RIT2 (Ras-Like Without CAAX 2 (RIT2))
    Épitope
    • 10
    • 10
    • 8
    • 5
    • 4
    • 1
    • 1
    • 1
    • 1
    AA 102-113, C-Term
    Reactivité
    • 37
    • 4
    • 2
    • 1
    • 1
    Humain
    Hôte
    • 26
    • 11
    Lapin
    Clonalité
    • 28
    • 9
    Polyclonal
    Conjugué
    • 21
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    Cet anticorp RIT2 est non-conjugé
    Application
    • 32
    • 22
    • 5
    • 3
    • 3
    • 1
    • 1
    Immunoprecipitation (IP), Western Blotting (WB)
    Attributs du produit
    Concentration Definition: by Refractometry
    Purification
    Antiserum
    Immunogène
    This antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids 102-113 of Human ROC2 coupled to KLH.
  • Indications d'application
    This antibody reacts with human ROC2 by western blot and immunoprecipitation.  The antibody immunoprecipitates in vitro translated protein and protein from overexpressing cell lysates (using HeLa and NIH-3T3, and others).  Coimmunoprecipitation of related proteins does occur.  A 12.6 kDa band corresponding to human ROC2 is detected. Most cell lines expressing ROC2 can be used as a positive control.  Researchers should determine optimal titers for other applications.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    85 mg/mL
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
  • Kamura, Koepp, Conrad, Skowyra, Moreland, Iliopoulos, Lane, Kaelin, Elledge, Conaway, Harper, Conaway: "Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase." dans: Science (New York, N.Y.), Vol. 284, Issue 5414, pp. 657-61, (1999) (PubMed).

    Ohta, Michel, Schottelius, Xiong: "ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity." dans: Molecular cell, Vol. 3, Issue 4, pp. 535-41, (1999) (PubMed).

    Seol, Feldman, Zachariae, Shevchenko, Correll, Lyapina, Chi, Galova, Claypool, Sandmeyer, Nasmyth, Deshaies, Shevchenko, Deshaies: "Cdc53/cullin and the essential Hrt1 RING-H2 subunit of SCF define a ubiquitin ligase module that activates the E2 enzyme Cdc34." dans: Genes & development, Vol. 13, Issue 12, pp. 1614-26, (1999) (PubMed).

  • Antigène
    RIT2 (Ras-Like Without CAAX 2 (RIT2))
    Autre désignation
    ROC2 (RIT2 Produits)
    Synonymes
    RIBA, RIN, ROC2, Rin, Rit1, Roc2, RIT2, Ras like without CAAX 2, Ras-like without CAAX 2, RIT2, Rit2
    Sujet
    ROC2 also known as RING-box protein 2, Rbx2, RING finger protein 7, Regulator of cullins 2, CKII beta-binding protein 1, and CKBBP1, is a probable component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. ROC2 appears to recruit the E2 ubiquitination enzyme through the RING-type zinc finger in a manner similar to CDC34, and brings it into close proximity to the substrate. ROC2 may play a role in protecting cells from apoptosis induced by redox agents.  ROC2 has a cytoplasmic and nuclear localization and is expressed in heart, liver, skeletal muscle and pancreas tissues, and at very low levels in brain, placenta and lung.  1,10-phenanthroline induces ROC2 expression. The RING-type zinc finger domain is essential for ubiquitin ligase activity. Phosphorylation by CK2 is required for efficient degradation of NFKBIA and CDKN1B.
    Synonyms: GTP binding protein Roc2 antibody, Ras like protein expressed in neurons antibody, Ras like without CAAX 2 antibody, Ras like without CAAX protein 2 antibody, RIBA antibody, Ric (Drosophila) like antibody, Ric like antibody, RIN antibody
    ID gène
    9616, 37538003
    UniProt
    Q9UBF6
    Pathways
    Neurotrophin Signaling Pathway
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