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APC2 anticorps (C-Term)

APC2 Reactivité: Humain IP, WB Hôte: Lapin Polyclonal unconjugated
Pubmed (2 références)
N° du produit ABIN233785
$658.50
Plus frais de port $45.00 et $20.00 pour carboglace
100 μL
Destination: Etats-Unis
Envoi sous 1 à 2 jours ouvrables
  • Antigène Voir toutes APC2 Anticorps
    APC2 (APC Regulator of WNT Signaling Pathway 2 (APC2))
    Épitope
    • 15
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 810-822, C-Term
    Reactivité
    • 35
    • 11
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    Humain
    Hôte
    • 34
    • 1
    Lapin
    Clonalité
    • 34
    • 1
    Polyclonal
    Conjugué
    • 18
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp APC2 est non-conjugé
    Application
    • 16
    • 13
    • 13
    • 11
    • 6
    • 6
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    Immunoprecipitation (IP), Western Blotting (WB)
    Attributs du produit
    Concentration Definition: by Refractometry
    Purification
    Antiserum
    Immunogène
    This antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids 810-822 of Human APC2 coupled to KLH.
  • Indications d'application
    This antibody reacts with human APC2 by western blot and immunoprecipitation.  The antibody immunoprecipitates in vitro translated protein and protein from overexpressing cell lysates (using HeLa and NIH-3T3, and others).  Coimmunoprecipitation of related proteins (APC11) does occur.  A 93.8 kDa band corresponding to human APC2 is detected. Most cell lines or tissues expressing APC2 can be used as a positive control.  Researchers should determine optimal titers for other applications.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    85 mg/mL
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
  • Zachariae, Shevchenko, Andrews, Ciosk, Galova, Stark, Mann, Nasmyth: "Mass spectrometric analysis of the anaphase-promoting complex from yeast: identification of a subunit related to cullins." dans: Science (New York, N.Y.), Vol. 279, Issue 5354, pp. 1216-9, (1998) (PubMed).

    Yu, Peters, King, Page, Hieter, Kirschner: "Identification of a cullin homology region in a subunit of the anaphase-promoting complex." dans: Science (New York, N.Y.), Vol. 279, Issue 5354, pp. 1219-22, (1998) (PubMed).

  • Antigène
    APC2 (APC Regulator of WNT Signaling Pathway 2 (APC2))
    Autre désignation
    Apc2 (APC2 Produits)
    Synonymes
    APCL, AI852447, R75424, APC2, WNT signaling pathway regulator, adenomatosis polyposis coli 2, APC2, Apc2
    Sujet
    APC2, also known as Anaphase promoting complex subunit 2, APC2, Cyclosome subunit 2, and ANAPC2, is a component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle.  The APC/cyclosome protein complex promotes metaphase-anaphase transition by ubiquitinating its specific substrates such as mitotic cyclins and anaphase inhibitors, which are subsequently degraded by the 26S proteasome. Biochemical studies have shown that the vertebrate APC contains at least eleven subunits. The composition of APC is highly conserved in organisms from yeast to humans. APC2 is a cullin family member that interacts through the cullin domain with ANAPC11 and UBCH10.
    Synonyms: ANAPC2 antibody, Anaphase promoting complex subunit 2 antibody, APC2 antibody, KIAA1406 antibody
    ID gène
    29882, 7019327
    UniProt
    Q9UJX6
    Pathways
    Signalisation WNT
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