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TP53BP2 anticorps (Internal Region)

TP53BP2 Reactivité: Humain ELISA, WB Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN233802
$658.50
Plus frais de port $45.00 et $20.00 pour carboglace
100 μg
Destination: Etats-Unis
Envoi sous 1 à 2 jours ouvrables
  • Antigène Voir toutes TP53BP2 Anticorps
    TP53BP2 (Tumor Protein P53 Binding Protein 2 (TP53BP2))
    Épitope
    • 12
    • 10
    • 8
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reactivité
    • 51
    • 14
    • 6
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 49
    • 2
    Lapin
    Clonalité
    • 42
    • 9
    Polyclonal
    Conjugué
    • 23
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Cet anticorp TP53BP2 est non-conjugé
    Application
    • 36
    • 23
    • 8
    • 6
    • 3
    • 2
    • 1
    • 1
    ELISA, Western Blotting (WB)
    Attributs du produit
    Concentration Definition: by UV absorbance at 280 nm
    Immunogène
    This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to an sequence of human ASPP2.
    Isotype
    IgG
  • Indications d'application
    This affinity purified antibody has been tested for use in ELISA and western blotting. Specific conditions for reactivity should be optimized by the end user.  Expect a band approximately 125 kDa in size corresponding to ASPP2 by western blotting in the appropriate cell lysate or extract.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    2.4 mg/mL
    Buffer
    0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
  • Antigène
    TP53BP2 (Tumor Protein P53 Binding Protein 2 (TP53BP2))
    Autre désignation
    ASPP2 (TP53BP2 Produits)
    Synonymes
    53BP2, ASPP2, BBP, P53BP2, PPP1R13A, TP53BP2, AI746547, Tp53bp2, X98550, Trp53bp2, wu:fa09h08, wu:fb04e08, zgc:85720, tumor protein p53 binding protein 2, tumor protein p53 binding protein 2 L homeolog, tumor protein p53 binding protein, 2b, transformation related protein 53 binding protein 2, tumor protein p53 binding protein, 2, tumor protein p53 binding protein, 2a, TP53BP2, tp53bp2.L, tp53bp2, tp53bp2b, Trp53bp2, Tp53bp2, tp53bp2a
    Sujet
    ASPP (ankyrin-repeat-, SH3-domain- proline-rich-region protein) proteins (ASPP1, ASPP2 and iASPP) represent a new family of p53 binding proteins.  ASPP1 and ASPP2 bind and enhance p53-mediated apoptosis.  In contrast, iASPP functionally inactivates p53.  ASPPs may also regulate p63- and p73-mediated apoptosis.  Both ASPP1 and 2 directly interact with p53 and specifically enhance the apoptotic function of p53 by stimulating its DNA binding and transactivation function on promoters of pro-apoptotic genes, such as Bax and PIG-3.  Not all cell cycle arrest genes are affected, such as p21.  Interestingly, expression of ASPP is frequently down-regulated in human breast carcinomas expressing wild-type p53 but not mutant p53.  Therefore, ASPP might regulate the tumor suppression function of p53 in vivo.
    Synonyms: Apoptosis stimulating of p53 protein 2 antibody, Bbp antibody, Bcl2 binding protein antibody, NY REN 51 antigen antibody, p53 binding protein 2 antibody
    ID gène
    7159, 112799849
    UniProt
    Q13625
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