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IL7R anticorps (pTyr449)

IL7R Reactivité: Souris IP, ELISA, WB Hôte: Lapin Polyclonal unconjugated
Pubmed (1 reference)
N° du produit ABIN233847
$658.50
Plus frais de port $45.00 et $20.00 pour carboglace
100 μg
Destination: Etats-Unis
Envoi sous 1 à 2 jours ouvrables
  • Antigène Voir toutes IL7R Anticorps
    IL7R (Interleukin 7 Receptor (IL7R))
    Épitope
    • 23
    • 16
    • 10
    • 7
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pTyr449
    Reactivité
    • 101
    • 55
    • 26
    • 7
    • 4
    • 2
    • 1
    Souris
    Hôte
    • 82
    • 27
    • 26
    • 7
    • 1
    Lapin
    Clonalité
    • 90
    • 52
    • 1
    Polyclonal
    Conjugué
    • 61
    • 12
    • 10
    • 8
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp IL7R est non-conjugé
    Application
    • 74
    • 60
    • 46
    • 26
    • 26
    • 12
    • 11
    • 8
    • 7
    • 6
    • 5
    • 3
    • 2
    • 1
    • 1
    Immunoprecipitation (IP), ELISA, Western Blotting (WB)
     Réactivité croisée
    Souris, Rat (Rattus)
    Attributs du produit
    Concentration Definition: by UV absorbance at 280 nm
    Immunogène
    This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to residues near Y449 of mouse IL-7 protein.
    Isotype
    IgG
  • Indications d'application
    This affinity purified antibody has been tested for use in ELISA, immunoprecipitation, and western blotting.  Specific conditions for reactivity should be optimized by the end user.  Expect a band approximately 55 kDa in size corresponding to phosphorylated IL-7 by western blotting in the appropriate cell lysate or extract.  This phospho-specific polyclonal antibody reacts with mouse IL-7 pY449 and shows minimal reactivity by ELISA against the non-phosphorylated form of the immunizing peptide.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.82 mg/mL
    Buffer
    0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
  • Osborne, Dhanji, Snow, Priatel, Ma, Miners, Teh, Goldsmith, Abraham: "Impaired CD8 T cell memory and CD4 T cell primary responses in IL-7R alpha mutant mice." dans: The Journal of experimental medicine, Vol. 204, Issue 3, pp. 619-31, (2007) (PubMed).

  • Antigène
    IL7R (Interleukin 7 Receptor (IL7R))
    Autre désignation
    IL-7 Receptor Alpha Chain (IL7R Produits)
    Synonymes
    IL7R, CD127, IL-7Ralpha, CDW127, IL-7R-alpha, IL7RA, ILRA, IL-7RA, interleukin 7 receptor, IL7R, Il7r
    Sujet
    This antibody is designed, produced, and is suitable for Cancer, Immunology and Nuclear Signaling research. Interleukin-7 is a glycoprotein involved in the regulation of lymphopoiesis. Response of cells to IL7 is dependent on the presence of the interleukin 7 receptor (IL7R); the active receptor is an alpha/gamma chain heterodimer. The gamma(c) chain, which also associates with the interleukin-2 receptor, serves primarily to activate signal transduction by the IL7R complex, while the alpha chain of IL7R determines specific signaling events through its association with cytoplasmic signaling molecules.  The human and mouse sequence is nearly identical.  In humans, severe combined immunodeficiency is caused by genetic defects in IL-7 receptor. The tyrosine residue at the 449 position is a critical signaling site of the intracellular domain of IL-7 receptor. This site is rapidly phosphorylated by janus kinases after the IL-7 receptor is engaged. IL-7 Receptor Alpha Chain phospho Y449 Antibody is ideal for investigators involved in Cell Signaling, Signal Transduction and Immunology research.
    Synonyms: IL7Ralpha antibody, Interleukin 7 receptor alpha chain antibody, Interleukin 7 receptor antibody
    ID gène
    16197, 45269152
    UniProt
    P16872
    Pathways
    Signalistation JAK/STAT, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Regulation of Cell Size
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