IRAK1BP1 anticorps

N° du produit ABIN2421755

Détail du produit anti-IRAK1BP1 anticorps

Antigène: IRAK1BP1 (Interleukin-1 Receptor-Associated Kinase 1 Binding Protein 1 (IRAK1BP1))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp IRAK1BP1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Purification: Affinity purification

Immunogène: Recombinant protein of human IRAK1BP1

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, IHC 1:50-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.4 mg/mL

Buffer: PBS with 0.05 % sodium azide and 50 % glycerol, PH7.4

Agent conservateur: Sodium azide

Conseil sur la manipulation: Avoid freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur IRAK1BP1

Antigène: IRAK1BP1 (Interleukin-1 Receptor-Associated Kinase 1 Binding Protein 1 (IRAK1BP1))

Autre désignation: IRAK1BP1 (IRAK1BP1 Produits)

Synonymes: anticorps AIP70, anticorps SIMPL, anticorps 4921528N06Rik, anticorps AI851240, anticorps Aabp3, anticorps Aip70, anticorps Simpl, anticorps zgc:112481, anticorps interleukin 1 receptor associated kinase 1 binding protein 1, anticorps interleukin-1 receptor-associated kinase 1 binding protein 1, anticorps IRAK1BP1, anticorps Irak1bp1, anticorps irak1bp1

Sujet: SIMPL, also known as IRAK1BP1 (interleukin-1 receptor-associated kinase 1-binding protein 1), is a 260 amino acid protein belonging to the IRAK1BP1 family. In addition to containing an intrinsically disordered region which associates with HSPA1 and HSPA8, SIMPL also interacts directly with IRAK1 and promotes RELA transcriptional activity. SIMPL is a major component of the IRAK1-dependent TNFRSF1A signaling pathway in which TNF-alpha induces NF-kappa-B gene transcription, leading to an inhibition of proinflammatory cytokines. Inactivation of SIMPL inhibits tumor necrosis factor receptor type I-induced NF-kappaB activity. Localizing to the nucleus and cytoplasm, SIMPL requires the phosphorylation of Ser-56 and/or Ser-62 to be fully active.

Poids moléculaire: Calculated MW: 29 kDa