DIO2 anticorps

N° du produit ABIN2432951

Détail du produit anti-DIO2 anticorps

Antigène: DIO2 (Deiodinase, Iodothyronine, Type II (DIO2))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DIO2 est non-conjugé

Application: Western Blotting (WB), ELISA

Purification: Affinity purification

Immunogène: Synthetic peptide of human DIO2

Isotype: IgG

Information d'application

Indications d'application: WB 1:200-1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.7 mg/mL

Buffer: PBS with 0.05 % sodium azide and 50 % glycerol, PH7.4

Agent conservateur: Sodium azide

Conseil sur la manipulation: Avoid freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur DIO2

Antigène: DIO2 (Deiodinase, Iodothyronine, Type II (DIO2))

Autre désignation: DIO2 (DIO2 Produits)

Synonymes: anticorps 5DII, anticorps D2, anticorps DIOII, anticorps SelY, anticorps TXDI2, anticorps AI324267, anticorps Deio2, anticorps cb684, anticorps DIO2, anticorps dio2-A, anticorps 5dii, anticorps sely, anticorps txdi2, anticorps iodothyronine deiodinase 2, anticorps deiodinase, iodothyronine, type II, anticorps deiodinase, iodothyronine, type 2 L homeolog, anticorps deiodinase, iodothyronine, type 2, anticorps type II iodothyronine deiodinase, anticorps DIO2, anticorps Dio2, anticorps dio2, anticorps dio2.L, anticorps LOC100861220

Sujet: The protein encoded by this gene belongs to the iodothyronine deiodinase family. It activates thyroid hormone by converting the prohormone thyroxine (T4) by outer ring deiodination (ORD) to bioactive 3,3',5-triiodothyronine (T3). It is highly expressed in the thyroid, and may contribute significantly to the relative increase in thyroidal T3 production in patients with Graves disease and thyroid adenomas. This protein contains selenocysteine (Sec) residues encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in multiple transcript variants encoding different isoforms.

Poids moléculaire: Calculated MW: 31 kDa

NCBI Accession: NP_000784

Pathways: Hormone Transport, Hormone Activity