anticorps HACE1, anticorps 1700042J16Rik, anticorps A730034A22Rik, anticorps BC025474, anticorps HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1, anticorps HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 L homeolog, anticorps HECT domain and ankyrin repeat containing, E3 ubiquitin protein ligase 1, anticorps HACE1, anticorps hace1, anticorps hace1.L, anticorps Hace1
Sujet
HACE1 (HECT domain and ankyrin repeat containing, E3 ubiquitin protein ligase 1), also known as KIAA1320, is a 909 amino acid protein that localizes to both the cytoplasm and the endoplasmic reticulum and contains one HECT domain and six ANK repeats. Expressed in kidney, heart and brain, HACE1 functions as an E3 ubiquitin-protein ligase that interacts with the proteasome and is thought to play a role in protein degradation. HACE1 is downregulated in Wilms tumor, suggesting a possible role in tumor suppression.