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CD40 anticorps (Extracellular Domain)

CD40 Reactivité: Humain FACS, IHC, St Hôte: Souris Monoclonal 5C3 unconjugated
N° du produit ABIN2451933
  • Antigène Voir toutes CD40 Anticorps
    CD40
    Épitope
    • 17
    • 16
    • 14
    • 13
    • 12
    • 12
    • 9
    • 5
    • 5
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Extracellular Domain
    Reactivité
    • 197
    • 114
    • 22
    • 20
    • 7
    • 6
    • 4
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Humain
    Hôte
    • 112
    • 100
    • 55
    • 6
    • 2
    • 1
    • 1
    • 1
    Souris
    Clonalité
    • 182
    • 89
    • 5
    Monoclonal
    Conjugué
    • 124
    • 26
    • 22
    • 21
    • 14
    • 8
    • 7
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp CD40 est non-conjugé
    Application
    • 157
    • 97
    • 64
    • 53
    • 32
    • 32
    • 20
    • 19
    • 17
    • 14
    • 13
    • 13
    • 8
    • 6
    • 5
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Flow Cytometry (FACS), Immunohistochemistry (IHC), Stimulation (St)
    Purification
    Purified from serum-free medium by salting-out and ion-exchange chromatography under mild conditions.
    Stérilité
    Sterile filtered
    Immunogène
    Recombinant extracellular domain of CD40 Product, Purified from serum-free medium by salting-out and ion-exchange chromatography under mild conditions.
    Clone
    5C3
    Isotype
    IgG1 kappa
    Top Product
    Discover our top product CD40 Anticorps primaire
  • Indications d'application
    1. Flowcytometry
    2. Immunohistochemistry (acetone or zinc-fixed or frozen section, indirect immuno-staining)
    3. Stimulation of proliferation of B cell and dendritic cells. Enhancement of proinflamentory cytokine production in human monocytes,such as TNF-a,IL-6 and IL-8
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    PBS, 50 % glycerol. Azide- and carrier protein-free.
    Agent conservateur
    Azide free
    Stock
    -20 °C
  • Ishida, Kumanogoh, Suzuki, Akahani, Noda, Kikutani: "Involvement of CD100, a lymphocyte semaphorin, in the activation of the human immune system via CD72: implications for the regulation of immune and inflammatory responses." dans: International immunology, Vol. 15, Issue 8, pp. 1027-34, (2003) (PubMed).

    Yasui, Muraoka, Takaoka-Shichijo, Ishida, Takegahara, Uchida, Kumanogoh, Suematsu, Suzuki, Kikutani: "Dissection of B cell differentiation during primary immune responses in mice with altered CD40 signals." dans: International immunology, Vol. 14, Issue 3, pp. 319-29, (2002) (PubMed).

    Inui, Kaisho, Kikutani, Stamenkovic, Seed, Clark, Kishimoto: "Identification of the intracytoplasmic region essential for signal transduction through a B cell activation molecule, CD40." dans: European journal of immunology, Vol. 20, Issue 8, pp. 1747-53, (1990) (PubMed).

  • Antigène
    CD40
    Autre désignation
    CD40 (CD40 Produits)
    Synonymes
    anticorps Bp50, anticorps CDW40, anticorps TNFRSF5, anticorps p50, anticorps AI326936, anticorps GP39, anticorps HIGM1, anticorps IGM, anticorps IMD3, anticorps T-BAM, anticorps TRAP, anticorps Tnfrsf5, anticorps TNFSF5, anticorps CD40 molecule, anticorps CD40 antigen, anticorps CD40, anticorps Cd40
    Sujet
    CD40 is a 45-50- kDa glycoprotein belonging to the tumor necrosis factor (TNF) receptor superfamily. CD40 is specifically expressed on the surface of B cells and specialized antigen-presenting cells such as dendritic cells and macrophages. CD40 interacts with the CD40 ligand (CD154) which is found primarily on T cells, playing a role in both humoral and cell-mediated immune responses. Activation of CD40 on B cells by CD40 ligand causes B cell proliferation, differentiation, immunoglobulin isotype switching, germinal center formation, and stimulation of the humoral memory response. CD40 has been found to mediate a broad variety of immune and inflammatory responses. Within the cell, the CD40 Molecule acts as a transmembrane signal transducer that leads to activation of intracellular kinases and transcription factors.
    UniProt
    P25942
    Pathways
    Signalisation NF-kappaB, Cellular Response to Molecule of Bacterial Origin, M Phase, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints
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