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Influenza Nucleoprotein anticorps (Influenza A Virus H2N2) (H1N1), (H2N2), (H3N2), (H5N1), (H5N2) (HRP)

NP Reactivité: Influenza A Virus H2N2 ELISA, WB, IHC, IC Hôte: Souris Monoclonal C43 HRP
N° du produit ABIN2452038
  • Antigène Voir toutes Influenza Nucleoprotein (NP) Anticorps
    Influenza Nucleoprotein (NP)
    Épitope
    • 15
    • 5
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    H1N1, H2N2, H3N2, H5N1, H5N2
    Reactivité
    • 64
    • 40
    • 15
    • 13
    • 11
    • 2
    • 1
    • 1
    • 1
    Influenza A Virus H2N2
    Hôte
    • 84
    • 44
    • 4
    Souris
    Clonalité
    • 86
    • 45
    Monoclonal
    Conjugué
    • 94
    • 10
    • 9
    • 6
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    HRP
    Application
    • 86
    • 57
    • 26
    • 15
    • 13
    • 13
    • 10
    • 9
    • 8
    • 7
    • 6
    • 6
    • 6
    • 3
    • 2
    • 2
    • 1
    ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunochromatography (IC)
    Specificité
    Reacts with NP of all influenza A viruses tested so far, including seasonal H2N2, H3N2, and avian H5N1, H5N2 and H1N1 (seasonal, pandemic and swine).
    Réactivité croisée (Details)
    No cross reactivity with influenza B viruses.
    Purification
    Produced in serum-free medium and purified by proprietary chromatography procedure under mild conditions.
    Stérilité
    Sterile filtered
    Immunogène
    Human Influenza A Virus (H2N2) Okada strain
    Clone
    C43
    Isotype
    IgG2a
    Top Product
    Discover our top product NP Anticorps primaire
  • Indications d'application
    1) Western blotting: 300~1,000 fold dilution
    2) Immunocytochemistry: ~200 fold dilution
    4) Immunohistochemistry: ~200 fold dilution
    5) ELISA (assay dependent)
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    PBS (x1), 50 % glycerol. Azide and carrier free.
    Agent conservateur
    Azide free
    Stock
    -20 °C
    Stockage commentaire
    Upon arrival centrifuge briefly and store at -20 C.
  • Mizuike, Sasaki, Baba, Iwamoto, Shibai, Kosaka, Kubota-Koketsu, Yang, Du, Sakudo, Tsujikawa, Yunoki, Ikuta: "Development of two types of rapid diagnostic test kits to detect the hemagglutinin or nucleoprotein of the swine-origin pandemic influenza A virus H1N1." dans: Clinical and vaccine immunology : CVI, Vol. 18, Issue 3, pp. 494-9, (2011) (PubMed).

    Ueda, Yamate, Du, Daidoji, Okuno, Ikuta, Nakaya: "Maturation efficiency of viral glycoproteins in the ER impacts the production of influenza A virus." dans: Virus research, Vol. 136, Issue 1-2, pp. 91-7, (2008) (PubMed).

    Okuno, Isegawa, Sasao, Ueda: "A common neutralizing epitope conserved between the hemagglutinins of influenza A virus H1 and H2 strains." dans: Journal of virology, Vol. 67, Issue 5, pp. 2552-8, (1993) (PubMed).

  • Antigène
    Influenza Nucleoprotein (NP)
    Autre désignation
    Influenza A (Nucleoprotein) (NP Produits)
    Synonymes
    anticorps nucleoprotein, anticorps NP
    Classe de substances
    Influenza Protein
    Sujet
    Influenza virus is an RNA virus, which causes influenza, and belongs to the family Orthomyxoviridae. Influenza virus is classified into three different genera, influenzavirus A, B, and C. They all have similar structures and compositions. The virions are 80-100nm in diameter and usually roughly spherical. The outer surface of the virion is made of a viral envelope containing two major glycoproteins, hemagglutinin (HA) and neuraminidase (NA). Influenzavirus A is further classified into subtypes based on the surface glycoproteins, HA and NA. Currently, there are 16 HA and 9 NA subtypes. The central core of the virion contains the viral RNA genome, which is packaged in the form of ribonucleoprotein complexes. Influenza virus nucleoprotein (NP) is a major component of the ribonucleoprotein complex and is abundantly expressed during the course of infection. It is a structural protein, which encapsidates the negative strand viral RNA and is essential for RNA transcription, replication and packaging. NP binds the PB1 and PB2 subunits of the viral RNA polymerase and the matrix protein M1, in addition to its binding to ssRNA. NP is also known to interact with variety of other macromolecules of both viral and cellular origins, and these interactions have been shown to be essential for the viral lifecycle.
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