Melanoma Antigen Family D, 1 (MAGED1) (AA 1-775) anticorps

Détails pour le produit réf. ABIN2452045
Antigène
  • MAGED1
  • DLXIN-1
  • NRAGE
  • 2810433C11Rik
  • 5430405L04Rik
  • DXBwg1492e
  • Dlixin
  • Dlxin-1
  • Dlxin1
  • MAGE-D1
  • mFLJ00163
  • Nrage
  • MAGE family member D1
  • melanoma antigen family D, 1
  • melanoma antigen, family D, 1
  • MAGED1
  • Maged1
Épitope
AA 1-775
9
7
6
6
3
3
2
2
2
2
2
1
1
1
Reactivité
Souris
99
60
59
2
2
2
2
1
1
1
1
1
1
Hôte
Lapin
91
11
2
Clonalité (Clone)
Monoclonal ()
Conjugué
Inconjugué
6
4
4
4
4
4
4
3
2
2
2
2
1
1
1
1
1
Application
Immunochromatography (IC), Immunofluorescence (IF), Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
70
43
35
13
8
4
2
2
1
1
Options
Immunogène Recombinant MBT-fused mouse MAGE-D1 (aa 1-775).
Clone MD1
Specificité React with mouse, rat and human MAGE-D1
Attributs du produit Antiserum
Purification Rabbit serum
Antigène
Autre désignation MAGE-D1 (MAGED1 Antibody Extrait)
Sujet MAGE-D1 (melanoma-associated antigen D1), also known as Dlxin-1 or NRAGE, is a member of the MAGE protein family. MAGE-D1 is expressed in almost all normal adult tissues and has been demonstrated to interact with the p75 neutrophin receptor and to facilitate nerve growth factor-dependent apoptosis. MAGE-D1 also interacts with its homologous protein, necdin, which is known as a growth suppressor and a promoter of differentiation in neurons. Necdin binds to Msx (msh homeobox) and Dlx (distal-less homeobox) family homeodomain transcription factors via MAGE-D1. These proteins cooperate to modulate differentiation of neurons and muscle cells by regulating gene expression whereas Msx proteins function as transcriptional repressor and Dlx proteins function as transcriptional activators (ref.2 and 3). An antibody (named MD1) against mouse MAGE-D1 was raised in rabbit.
UniProt Q9QYH6, Q9ES73, Q9Y5V3
Pathways Neurotrophin Signaling Pathway
Indications d'application 1. Western blotting: 1/3,000-1/1,000
2. Immunohistochemistry: 1/300
3. Immunocytochemistry: 1/1,000-1/500)
4. ELISA Not tested for other applications
Restrictions For Research Use only
Format Liquid
Buffer 0.05 % sodium azide
Agent conservateur Sodium azide
Précaution d'utilisation This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock -20 °C
Images (Fournisseur)
Western Blotting (WB) image for anti-Melanoma Antigen Family D, 1 (MAGED1) (AA 1-775) antibody (ABIN2452045) anti-Melanoma Antigen Family D, 1 (MAGED1) (AA 1-775) antibody
Immunohistochemistry (IHC) image for anti-Melanoma Antigen Family D, 1 (MAGED1) (AA 1-775) antibody (ABIN2452045) anti-Melanoma Antigen Family D, 1 (MAGED1) (AA 1-775) antibody (Image 2)
Western Blotting (WB) image for anti-Melanoma Antigen Family D, 1 (MAGED1) (AA 1-775) antibody (ABIN2452045) anti-Melanoma Antigen Family D, 1 (MAGED1) (AA 1-775) antibody (Image 3)
Immunofluorescence (IF) image for anti-Melanoma Antigen Family D, 1 (MAGED1) (AA 1-775) antibody (ABIN2452045) anti-Melanoma Antigen Family D, 1 (MAGED1) (AA 1-775) antibody (Image 4)
Immunofluorescence (IF) image for anti-Melanoma Antigen Family D, 1 (MAGED1) (AA 1-775) antibody (ABIN2452045) anti-Melanoma Antigen Family D, 1 (MAGED1) (AA 1-775) antibody (Image 5)
Western Blotting (WB) image for anti-Melanoma Antigen Family D, 1 (MAGED1) (AA 1-775) antibody (ABIN2452045) anti-Melanoma Antigen Family D, 1 (MAGED1) (AA 1-775) antibody (Image 6)
Background publications Kuwajima, Nishimura, Yoshikawa: "Necdin promotes GABAergic neuron differentiation in cooperation with Dlx homeodomain proteins." dans: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 26, Issue 20, pp. 5383-92, 2006 (PubMed).

Produit citée dans: Kuwajima, Taniura, Nishimura, Yoshikawa: "Necdin interacts with the Msx2 homeodomain protein via MAGE-D1 to promote myogenic differentiation of C2C12 cells." dans: The Journal of biological chemistry, Vol. 279, Issue 39, pp. 40484-93, 2004 (PubMed).

Salehi, Roux, Kubu, Zeindler, Bhakar, Tannis, Verdi, Barker: "NRAGE, a novel MAGE protein, interacts with the p75 neurotrophin receptor and facilitates nerve growth factor-dependent apoptosis." dans: Neuron, Vol. 27, Issue 2, pp. 279-88, 2000 (PubMed).

Avez-vous cherché autre chose?