NFX1 anticorps

N° du produit ABIN2458113

Détail du produit anti-NFX1 anticorps

Antigène: NFX1 (Nuclear Transcription Factor, X-Box Binding 1 (NFX1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NFX1 est non-conjugé

Application: Western Blotting (WB), ELISA

Purification: Antibody is purified by peptide affinity chromatography method.

Immunogène: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human NFX1.

Information d'application

Indications d'application: NFX1 antibody can be used for detection of NFX1 by ELISA at 1:62500. NFX1 antibody can be used for detection of NFX1 by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Concentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Conseil sur la manipulation: As with any antibody avoid repeat freeze-thaw cycles.

Stock: 4 °C/-20 °C

Stockage commentaire: For short periods of storage (days) store at 4 °C. For longer periods of storage, store NFX1 antibody at -20 °C.

Détails sur NFX1

Antigène: NFX1 (Nuclear Transcription Factor, X-Box Binding 1 (NFX1))

Autre désignation: NFX1 (NFX1 Produits)

Synonymes: anticorps NFX1, anticorps NFX2, anticorps 1300017N15Rik, anticorps 3000003M19Rik, anticorps NFX.1, anticorps TEG-42, anticorps Tex42, anticorps nuclear transcription factor, X-box binding 1, anticorps nuclear transcription factor, x-box binding 1, anticorps NFX1, anticorps CpipJ_CPIJ011986, anticorps nfx1, anticorps Nfx1

Sujet: NFX1 binds to the X-box motif of MHC class II genes and represses their expression. NFX1 may play an important role in regulating the duration of an inflammatory response by limiting the period in which MHC class II molecules are induced by interferon-gamma. Isoform 3 binds to the X-box motif of TERT promoter and represses its expression. Together with PABPC1 or PABPC4, isoform 1 acts as a coactivator for TERT expression. NFX1 mediates E2-dependent ubiquitination.MHC class II gene expression is controlled primarily at the transcriptional level by transcription factors that bind to the X and Y boxes, two highly conserved elements in the proximal promoter of MHC class II genes. The protein encoded by this gene is a transcriptional repressor capable of binding to the conserved X box motif of HLA-DRA and other MHC class II genes in vitro. The protein may play a role in regulating the duration of an inflammatory response by limiting the period in which class II MHC molecules are induced by IFN-gamma. Three alternative splice variants, each of which encodes a different isoform, have been identified.

Poids moléculaire: 113 kDa

ID gène: 4799

NCBI Accession: NP_667344