PTBP1 anticorps

N° du produit ABIN2458494

Détail du produit anti-PTBP1 anticorps

Antigène: PTBP1 (Polypyrimidine Tract Binding Protein 1 (PTBP1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PTBP1 est non-conjugé

Application: Western Blotting (WB), ELISA

Purification: Antibody is purified by peptide affinity chromatography method.

Immunogène: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human PTBP1.

Information d'application

Indications d'application: PTBP1 antibody can be used for detection of PTBP1 by ELISA at 1:12500. PTBP1 antibody can be used for detection of PTBP1 by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Concentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Conseil sur la manipulation: As with any antibody avoid repeat freeze-thaw cycles.

Stock: 4 °C/-20 °C

Stockage commentaire: For short periods of storage (days) store at 4 °C. For longer periods of storage, store PTBP1 antibody at -20 °C.

Détails sur PTBP1

Antigène: PTBP1 (Polypyrimidine Tract Binding Protein 1 (PTBP1))

Autre désignation: PTBP1 (PTBP1 Produits)

Synonymes: anticorps HNRNP-I, anticorps HNRNPI, anticorps HNRPI, anticorps PTB, anticorps PTB-1, anticorps PTB-T, anticorps PTB2, anticorps PTB3, anticorps PTB4, anticorps pPTB, anticorps Ptb, anticorps hnrpi, anticorps hnrnp-I, anticorps vgrbp60, anticorps AA407203, anticorps AL033359, anticorps Pybp, anticorps Pybp1, anticorps Pybp2, anticorps ptbp1, anticorps wu:fb99f12, anticorps zgc:110689, anticorps ptb, anticorps ATPTB1, anticorps POLYPYRIMIDINE TRACT-BINDING, anticorps POLYPYRIMIDINE TRACT-BINDING PROTEIN 1, anticorps T4P13.16, anticorps T4P13_16, anticorps polypyrimidine tract-binding protein 1, anticorps PTBP1, anticorps polypyrimidine tract binding protein 1, anticorps polypyrimidine tract binding protein 1 S homeolog, anticorps polypyrimidine tract-binding protein, anticorps polypyrimidine tract binding protein 1a, anticorps polypyrimidine tract binding protein 1 L homeolog, anticorps polypyrimidine tract-binding protein 1, anticorps PTBP1, anticorps ptbp1.S, anticorps NAEGRDRAFT_80143, anticorps LOC100285404, anticorps Ptbp1, anticorps ptbp1a, anticorps ptbp1.L, anticorps PTB1, anticorps LOC100061673

Sujet: PTBP1 belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA-binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. This protein binds to the intronic polypyrimidine tracts that requires pre-mRNA splicing and acts via the protein degradation ubiquitin-proteasome pathway. It may also promote the binding of U2 snRNP to pre-mRNAs. This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA-binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has four repeats of quasi-RNA recognition motif (RRM) domains that bind RNAs. This protein binds to the intronic polypyrimidine tracts that requires pre-mRNA splicing and acts via the protein degradation ubiquitin-proteasome pathway. It may also promote the binding of U2 snRNP to pre-mRNAs. This protein is localized in the nucleoplasm and it is also detected in the perinucleolar structure. Alternatively spliced transcript variants encoding different isoforms have been described.

Poids moléculaire: 60 kDa

ID gène: 5725

NCBI Accession: NP_002810

UniProt: Q29099

Pathways: Regulation of Muscle Cell Differentiation