PADI2 anticorps

N° du produit ABIN2463506

Détail du produit anti-PADI2 anticorps

Antigène: PADI2 (Peptidyl Arginine Deiminase, Type II (PADI2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PADI2 est non-conjugé

Application: Western Blotting (WB), ELISA

Purification: Antibody is purified by peptide affinity chromatography method.

Immunogène: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human PADI2.

Information d'application

Indications d'application: PADI2 antibody can be used for detection of PADI2 by ELISA at 1:12500. PADI2 antibody can be used for detection of PADI2 by western blot at 0.5 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Concentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Conseil sur la manipulation: As with any antibody avoid repeat freeze-thaw cycles.

Stock: 4 °C/-20 °C

Stockage commentaire: For short periods of storage (days) store at 4 °C. For longer periods of storage, store PADI2 antibody at -20 °C.

Détails sur PADI2

Antigène: PADI2 (Peptidyl Arginine Deiminase, Type II (PADI2))

Autre désignation: PADI2 (PADI2 Produits)

Synonymes: anticorps PADI2, anticorps PAD-H19, anticorps PAD2, anticorps PDI2, anticorps Pdi, anticorps Pdi2, anticorps mKIAA0994, anticorps peptidyl arginine deiminase 2, anticorps peptidyl arginine deiminase, type II, anticorps protein-arginine deiminase type-2, anticorps peptidyl arginine deiminase, type II S homeolog, anticorps PADI2, anticorps padi2, anticorps LOC100357368, anticorps padi2.S, anticorps Padi2

Sujet: PADI2 encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type II enzyme is the most widely expressed family member. Known substrates for this enzyme include myelin basic protein in the central nervous system and vimentin in skeletal muscle and macrophages. PADI2 is thought to play a role in the onset and progression of neurodegenerative human disorders, including Alzheimer disease and multiple sclerosis, and it has also been implicated in glaucoma pathogenesis.This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type II enzyme is the most widely expressed family member. Known substrates for this enzyme include myelin basic protein in the central nervous system and vimentin in skeletal muscle and macrophages. This enzyme is thought to play a role in the onset and progression of neurodegenerative human disorders, including Alzheimer disease and multiple sclerosis, and it has also been implicated in glaucoma pathogenesis. This gene exists in a cluster with four other paralogous genes. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Poids moléculaire: 75 kDa

ID gène: 11240

NCBI Accession: NP_031391

UniProt: Q9Y2J8