ADRA2B anticorps (AA 200-299)

N° du produit ABIN2467937

Détail du produit anti-ADRA2B anticorps

Antigène: ADRA2B (Adrenergic, alpha-2B-, Receptor (ADRA2B))

Épitope: AA 200-299

Reactivité: Humain

Hôte: Poulet

Clonalité: Polyclonal

Conjugué: Cet anticorp ADRA2B est non-conjugé

Application: Western Blotting (WB)

Purification: Immunoaffinity Purified

Information d'application

Indications d'application: alpha-2B adrenergic receptor antibody can be used for the detection of alpha-2B adrenergic receptor by Western Blot.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Phosphate-Buffered Saline. No preservatives added.

Agent conservateur: Without preservative

Conseil sur la manipulation: As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Stock: 4 °C/-20 °C

Stockage commentaire: ADRA2B antibody can be stored at 4 °C for short term (weeks). Long term storage should be at -20 °C.

Détails sur ADRA2B

Antigène: ADRA2B (Adrenergic, alpha-2B-, Receptor (ADRA2B))

Autre désignation: ADRA2B (ADRA2B Produits)

Synonymes: anticorps ADRA2L1, anticorps ADRA2RL1, anticorps ADRARL1, anticorps ALPHA2BAR, anticorps alpha-2BAR, anticorps Adra-2b, anticorps [a]2B, anticorps alpha2-C2, anticorps alpha2B, anticorps ADRA2B, anticorps zgc:194747, anticorps Adra2b, anticorps adrenoceptor alpha 2B, anticorps adrenergic receptor, alpha 2b, anticorps adrenergic, alpha-2B-, receptor, anticorps adrenoceptor alpha 2C, anticorps ADRA2B, anticorps Adra2b, anticorps ADRA2C, anticorps adra2b

Sujet: FUNCTION: alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is clonidine > norepinephrine > epinephrine = oxymetazoline > dopamine > p-tyramine = phenylephrine > serotonin > p-synephrine / p-octopamine. For antagonists, the rank order is yohimbine > chlorpromazine > phentolamine > mianserine > spiperone > prazosin > alprenolol > propanolol > pindolol.

SUMMARY: alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. This protein is the alpha2B subtype, which was observed to associate with eIF-2B, a guanine nucleotide exchange protein that functions in regulation of translation. A polymorphic variant of the alpha2B subtype, which lacks 3 glutamic acids from a glutamic acid repeat element, was identified to have decreased G protein-coupled receptor kinase-mediated phosphorylation and desensitization, this polymorphic form is also associated with reduced basal metabolic rate in obese subjects and may therefore contribute to the pathogenesis of obesity. This protein contains no introns in either its coding or untranslated sequences.

Poids moléculaire: 50 kDa (calculated)

ID gène: 151

NCBI Accession: NP_000673

UniProt: P18089

Pathways: EGFR Signaling Pathway, cAMP Metabolic Process