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HCN2 anticorps (AA 761-863) (Atto 390)

HCN2 Reactivité: Rat WB, IHC, IP, IF, ICC, AA Hôte: Souris Monoclonal S71 Atto 390
N° du produit ABIN2481376
  • Antigène Voir toutes HCN2 Anticorps
    HCN2 (Hyperpolarization Activated Cyclic Nucleotide-Gated Potassium Channel 2 (HCN2))
    Épitope
    • 10
    • 6
    • 5
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 761-863
    Reactivité
    • 24
    • 21
    • 10
    • 1
    Rat
    Hôte
    • 26
    • 12
    Souris
    Clonalité
    • 26
    • 12
    Monoclonal
    Conjugué
    • 20
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp HCN2 est conjugé à/à la Atto 390
    Application
    • 29
    • 19
    • 15
    • 13
    • 13
    • 12
    • 10
    • 3
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF), Immunocytochemistry (ICC), Antibody Array (AA)
    Specificité
    Detects ~95 kDa. No cross-reactivity against HCN1.
     Réactivité croisée
    Humain, Souris, Rat
    Purification
    Protein G Purified
    Immunogène
    Fusion protein amino acids 761-863 (cytoplasmic C-terminus) of rat HCN2
    Clone
    S71
    Isotype
    IgG1
    Top Product
    Discover our top product HCN2 Anticorps primaire
  • Indications d'application
    • WB (1:1000)
    • IHC (1:1000)
    • ICC/IF (1:100)
    • optimal dilutions for assays should be determined by the user.
    Commentaires

    1 μg/ml of ABIN2481376 was sufficient for detection of HCN2 in 10 μg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C
    Stockage commentaire
    Conjugated antibodies should be stored at 4°C
  • Antigène
    HCN2 (Hyperpolarization Activated Cyclic Nucleotide-Gated Potassium Channel 2 (HCN2))
    Autre désignation
    HCN2 (HCN2 Produits)
    Synonymes
    anticorps HCN2, anticorps BCNG-2, anticorps BCNG2, anticorps HAC-1, anticorps HAC1, anticorps trls, anticorps hyperpolarization activated cyclic nucleotide-gated potassium channel 2, anticorps hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2, anticorps hyperpolarization-activated, cyclic nucleotide-gated K+ 2, anticorps LOC428335, anticorps HCN2, anticorps Hcn2
    Sujet
    Hyperpolarization-activated cyclic nucleotide-gated ion channel 2 (HCN2) is an integral membrane protein that helps establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient (1). Ion channels are present in the membranes that surround all biological cells because their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge, others conduct based on a ionic species, such as sodium or potassium. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or mechanical forces. There are a few main classifications of gated ion channels. There are voltage- gated ion channels, ligand- gated, other gating systems and finally those that are classified differently, having more exotic characteristics. The first are voltage- gated ion channels which open and close in response to membrane potential. These are then separated into sodium, calcium, potassium, proton, transient receptor, and cyclic nucleotide-gated channels, each of which is responsible for a unique role. Ligand-gated ion channels are also known as ionotropic receptors, and they open in response to specific ligand molecules binding to the extracellular domain of the receptor protein. The other gated classifications include activation and inactivation by second messengers, inward-rectifier potassium channels, calcium-activated potassium channels, two-pore-domain potassium channels, light-gated channels, mechano-sensitive ion channels and cyclic nucleotide-gated channels. Finally, the other classifications are based on less normal characteristics such as two-pore channels, and transient receptor potential channels (2). Specifically, hyperpolarization-activated cation channels of the HCN gene family contribute to spontaneous rhythmic activity in both the heart and brain (3).
    ID gène
    114244
    NCBI Accession
    NP_446136
    UniProt
    Q9JKA9
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