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Calcineurin A anticorps (AA 264-283) (Atto 488)

CAN Reactivité: Humain WB, IP, IHC, ICC, IF Hôte: Lapin Polyclonal Atto 488
N° du produit ABIN2481975
  • Antigène Voir toutes Calcineurin A (CAN) Anticorps
    Calcineurin A (CAN)
    Épitope
    • 11
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 264-283
    Reactivité
    • 28
    • 15
    • 13
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 29
    • 2
    • 1
    Lapin
    Clonalité
    • 21
    • 10
    Polyclonal
    Conjugué
    • 15
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp Calcineurin A est conjugé à/à la Atto 488
    Application
    • 20
    • 13
    • 12
    • 12
    • 11
    • 6
    • 2
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF)
    Specificité
    Detects ~61 kDa.
     Réactivité croisée
    Chien, Humain, Souris, Lapin, Rat
    Purification
    Peptide Affinity Purified
    Immunogène
    Human Calcineurin A peptide (AA 264-283)
    Top Product
    Discover our top product CAN Anticorps primaire
  • Indications d'application
    • WB (1:1000)
    • ICC/IF (1:120)
    • IHC (1:100)
    • optimal dilutions for assays should be determined by the user.
    Commentaires

    1 μg/ml of ABIN2481975 was sufficient for detection of Calcineurin A in 20 μg of Heat shock Hela lysate by colorimetric immunoblot analysis using Goat anti-rabbit IgG:HRP as the secondary antibody.

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C
    Stockage commentaire
    Conjugated antibodies should be stored at 4°C
  • Antigène
    Calcineurin A (CAN)
    Autre désignation
    Calcineurin A (CAN Produits)
    Synonymes
    anticorps Cna, anticorps DDBDRAFT_0185021, anticorps DDBDRAFT_0217855, anticorps DDB_0185021, anticorps DDB_0217855, anticorps PPP3CC, anticorps CAN A1/PP2B, anticorps CG1455, anticorps CNA1, anticorps Can, anticorps Cana1, anticorps CnA, anticorps CnnA21EF, anticorps D14, anticorps DmCanA1-100B, anticorps Dmel\\CG1455, anticorps PP2B, anticorps PP2B 21EF, anticorps PpD14, anticorps canA, anticorps pMY4, anticorps calcineurin A, anticorps Calcineurin A, anticorps CaM-dependent protein phosphatase, catalytic subunit, anticorps protein phosphatase 3 catalytic subunit alpha, anticorps Calcineurin A1, anticorps protein phosphatase 3 catalytic subunit beta, anticorps Cna, anticorps NFIA_077970, anticorps ACLA_011200, anticorps PAS_chr3_0414, anticorps canA, anticorps PPP3CA, anticorps CanA1, anticorps PPP3CB
    Sujet
    Calcineurin is a heterodimeric phosphatase protein, also known as calcium-dependent serine-threonine phosphatase. The structure consists of a catalytic subunit alpha, Calcineurin A (57-59KDa) the active site and a Ca2+ binding unit, Calcineurin B (19-20KDa) the regulatory subunit(1). Calcineurin plays a key role in the T-cell response growth and differentiation mechanism, regulating the activation of the Nuclear factor of activated T-cells (NFATc) which are important in the expression of IL-2 genes. Calcineurin has been the target of inhibitors, the novel and structural immune-suppressants antifungal drugs(2). Genetic studies in yeast and fungi established the molecular basis of the inhibition mechanism by cyclosporine A and FK506 (3).
    ID gène
    5530
    UniProt
    Q08209
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