SERPINH1 anticorps (Atto 488)

N° du produit ABIN2484363

Détail du produit anti-SERPINH1 anticorps (Atto 488)

Antigène: SERPINH1 (Serpin Family H Member 1 (SERPINH1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp SERPINH1 est conjugé à/à la Atto 488

Application: Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificité: Detects 47 kDa.

Réactivité croisée: Humain

Purification: Protein G Purified

Immunogène: Human HSP47, full length

Clone: 1C4-1A6

Isotype: IgG1 kappa

Information d'application

Indications d'application:

• WB (1:1000)
• ICC/IF (1:100)
• optimal dilutions for assays should be determined by the user.

Commentaires:

1 μg/ml of ABIN2484363 was sufficient for detection of HSP47 in 20 μg of heat shocked HeLa cell lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Conjugated antibodies should be stored at 4°C

Détails sur SERPINH1

Antigène: SERPINH1 (Serpin Family H Member 1 (SERPINH1))

Autre désignation: HSP47 (SERPINH1 Produits)

Synonymes: anticorps AsTP3, anticorps CBP1, anticorps CBP2, anticorps HSP47, anticorps OI10, anticorps PPROM, anticorps RA-A47, anticorps SERPINH2, anticorps gp46, anticorps SERPINH1, anticorps DKFZp468B197, anticorps cb216, anticorps hsp, anticorps hsp47, anticorps id:ibd5060, anticorps wu:fc56b02, anticorps BERF-1, anticorps Cbp1, anticorps Cbp2, anticorps Hsp47, anticorps J6, anticorps Serpinh2, anticorps colligin, anticorps astp3, anticorps cbp1, anticorps cbp2, anticorps pig14, anticorps pprom, anticorps ra-a47, anticorps serpinh2, anticorps serpin family H member 1, anticorps serpin peptidase inhibitor, clade H (heat shock protein 47), member 1b, anticorps serpin H1, anticorps selenoprotein K, anticorps serine (or cysteine) peptidase inhibitor, clade H, member 1, anticorps serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) L homeolog, anticorps SERPINH1, anticorps serpinh1b, anticorps LOC100009353, anticorps Selenok, anticorps Serpinh1, anticorps serpinh1.L

Sujet: HSP47 is a chaperone protein, member of the superfamily of serine proteinase inhibitors. Also known as SERPINH1, a serine proteinase inhibitor. It is a stress protein that resides in the endoplasmic reticulum, has an active role on the intracellular process of folding, assembly and secretion of pro-collagens. Recent studies have shown the association of on an increased expression of HSP47 around fibrotic lesions (1). The identification of a novel biomarker on cell therapies aimed to reduce the progression of fibrotic diseases, could be used potentially as a universal marker, since HSP47 binds a single substrate (2). Type I collagen is fundamental during the healing process after a myocardial infarction. It is critical in the position of collagen-produced cells and the assembly of collagen fibrils (3).

ID gène: 871

NCBI Accession: NP_001193943

UniProt: P50454