SCN3B anticorps (AA 1-215) (Biotin)

N° du produit ABIN2485586

Détail du produit anti-SCN3B anticorps (Biotin)

Antigène: SCN3B (Sodium Channel, Voltage-Gated, Type III, beta Subunit (SCN3B))

Épitope: AA 1-215

Reactivité: Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp SCN3B est conjugé à/à la Biotin

Application: Western Blotting (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)

Specificité: Detects ~40 kDa. Does not cross-reat with NavBeta1, Navbeta2, or Navbeta4.

Réactivité croisée: Humain, Souris, Rat

Purification: Protein G Purified

Immunogène: Fusion protein amino acids 1-215 (full-length) of rat NavBeta3

Clone: S396-29

Isotype: IgG2b

Information d'application

Indications d'application:

• WB (1:1000)
• ICC/IF (1:100)
• optimal dilutions for assays should be determined by the user.

Commentaires:

A 1:100 dilution of ABIN2485586 was sufficient for detection of NavBeta3 in 20 μg of mouse brain lysate by ECL immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS pH 7.4, 50 % glycerol, 0.1 % sodium azide, Storage buffer may change when conjugated

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Conjugated antibodies should be stored at 4°C

Détails sur SCN3B

Antigène: SCN3B (Sodium Channel, Voltage-Gated, Type III, beta Subunit (SCN3B))

Autre désignation: NaVbeta3 (SCN3B Produits)

Synonymes: anticorps 1110001K16Rik, anticorps 4833414B02Rik, anticorps Scnb3, anticorps HSA243396, anticorps SCNB3, anticorps sodium voltage-gated channel beta subunit 3, anticorps sodium channel, voltage-gated, type III, beta, anticorps SCN3B, anticorps Scn3b

Sujet: Nav Beta 3 (SCN3B) belongs to the voltage-gated sodium channel group, and modulates channel gating kinetics. It inactivates the sodium channel opening more slowly than its Beta1 subunit. It is also unique in causing persistent sodium currents which are thought to amplify summation of synaptic imputs which is likely to increase the excitability of specific neurons to their individual inputs (2). Its association with neurofascin may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons (1, 2). Defects in SCN3B are the cause of Brugada syndrome (3).

ID gène: 245956

NCBI Accession: NP_620797

UniProt: Q9JK00