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SCNN1A anticorps (AA 617-638) (PE)

SCNN1A Reactivité: Rat WB, IHC, IF, IP, ICC Hôte: Lapin Polyclonal PE
N° du produit ABIN2486415
  • Antigène Voir toutes SCNN1A Anticorps
    SCNN1A (Sodium Channel, Nonvoltage-Gated 1 alpha (SCNN1A))
    Épitope
    • 63
    • 22
    • 20
    • 11
    • 10
    • 7
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 617-638
    Reactivité
    • 99
    • 45
    • 39
    • 20
    • 10
    Rat
    Hôte
    • 82
    • 43
    Lapin
    Clonalité
    • 82
    • 43
    Polyclonal
    Conjugué
    • 28
    • 11
    • 10
    • 10
    • 10
    • 9
    • 9
    • 9
    • 9
    • 9
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp SCNN1A est conjugé à/à la PE
    Application
    • 115
    • 103
    • 36
    • 35
    • 33
    • 21
    • 10
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP), Immunocytochemistry (ICC)
    Specificité
    Detects ~87 kDa.
     Réactivité croisée
    Hamster, Humain, Souris, Rat, Xenopus laevis
    Purification
    Protein A Purified
    Immunogène
    Produced against the C-terminal tail (amino acids 617-638) of rat beta ENaC (antibody designation 3755-2)
    Top Product
    Discover our top product SCNN1A Anticorps primaire
  • Indications d'application
    • WB (1:1000)
    • IHC (1:100)
    • optimal dilutions for assays should be determined by the user.
    Commentaires

    1 μg/ml of ABIN2486415 was sufficient for detection of beta-ENaC in 20 μg of rat kidney tissue lysate by colorimetric immunoblot analysis using Goat anti-rabbit IgG:HRP as the secondary antibody.

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    PBS, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C
    Stockage commentaire
    Conjugated antibodies should be stored at 4°C
  • Antigène
    SCNN1A (Sodium Channel, Nonvoltage-Gated 1 alpha (SCNN1A))
    Autre désignation
    ENaC (SCNN1A Produits)
    Synonymes
    anticorps BESC2, anticorps ENaCa, anticorps ENaCalpha, anticorps SCNEA, anticorps SCNN1, anticorps ENaC, anticorps Scnn1, anticorps mENaC, anticorps SCNN1A, anticorps alphaxENaC, anticorps besc2, anticorps enaca, anticorps scnn1, anticorps ENAC, anticorps sodium channel epithelial 1 alpha subunit, anticorps sodium channel, nonvoltage-gated 1 alpha, anticorps sodium channel, non voltage gated 1 alpha subunit L homeolog, anticorps Scnn1a, anticorps SCNN1A, anticorps scnn1a.L
    Sujet
    The Epithelial Sodium Channel (ENaC) is a membrane ion channel permeable to Na+ ions. It is located in the apical plasma membrane of epithelia in the kidneys, lung, colon, and other tissues where it plays a role in trans epithelial Na+-ion transport (1). Specifically Na+ transport via ENaC occurs across many epithelial surfaces, and plays a key role in regulating salt and water absorption (2). ENaCs are composed of three structurally related subunits that form a tetrameric channel, α, β, and γ. The expression of its alpha and beta subunits is enhanced as keratinocytes differentiate (3, 4). The beta and gamma-ENaC subunits are essential for edema fluid to exert its maximal effect on net fluid absorption by distal lung epithelia(5). And it has been concluded that the subunits are differentially expressed in the retina of mice with ocular hypertension, therefore the up-regulation of alpha-ENaC proteins could serve as a protection mechanism against elevated intraocular pressure (6).
    ID gène
    24767
    NCBI Accession
    NP_036780
    UniProt
    P37090
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