SCNN1A anticorps (AA 629-650) (FITC)
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- Antigène Voir toutes SCNN1A Anticorps
- SCNN1A (Sodium Channel, Nonvoltage-Gated 1 alpha (SCNN1A))
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Épitope
- AA 629-650
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Reactivité
- Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp SCNN1A est conjugé à/à la FITC
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Application
- Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
- Specificité
- Detects ~83 kDa.
- Réactivité croisée
- Hamster, Humain, Souris, Rat, Xenopus laevis
- Purification
- Protein A Purified
- Immunogène
- Produced against the C-terminal tail (amino acids 629-650) of rat gamma ENaC (antibody designation L550)
- Top Product
- Discover our top product SCNN1A Anticorps primaire
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- Indications d'application
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- WB (1:1000)
- IHC (1:100)
- optimal dilutions for assays should be determined by the user.
- Commentaires
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1 μg/ml of ABIN2486428 was sufficient for detection of gamma-ENaC in 20 μg of rat kidney tissue lysate by colorimetric immunoblot analysis using Goat anti-rabbit IgG:HRP as the secondary antibody.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- PBS, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C
- Stockage commentaire
- Conjugated antibodies should be stored at 4°C
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- Antigène
- SCNN1A (Sodium Channel, Nonvoltage-Gated 1 alpha (SCNN1A))
- Autre désignation
- ENaC (SCNN1A Produits)
- Synonymes
- anticorps BESC2, anticorps ENaCa, anticorps ENaCalpha, anticorps SCNEA, anticorps SCNN1, anticorps ENaC, anticorps Scnn1, anticorps mENaC, anticorps SCNN1A, anticorps alphaxENaC, anticorps besc2, anticorps enaca, anticorps scnn1, anticorps ENAC, anticorps sodium channel epithelial 1 alpha subunit, anticorps sodium channel, nonvoltage-gated 1 alpha, anticorps sodium channel, non voltage gated 1 alpha subunit L homeolog, anticorps Scnn1a, anticorps SCNN1A, anticorps scnn1a.L
- Sujet
- The Epithelial Sodium Channel (ENaC) is a membrane ion channel permeable to Na+ ions. It is located in the apical plasma membrane of epithelia in the kidneys, lung, colon, and other tissues where it plays a role in trans epithelial Na+-ion transport (1). Specifically Na+ transport via ENaC occurs across many epithelial surfaces, and plays a key role in regulating salt and water absorption (2). ENaCs are composed of three structurally related subunits that form a tetrameric channel, α, β, and γ. The expression of its alpha and beta subunits is enhanced as keratinocytes differentiate (3, 4). The beta and gamma-ENaC subunits are essential for edema fluid to exert its maximal effect on net fluid absorption by distal lung epithelia(5). And it has been concluded that the subunits are differentially expressed in the retina of mice with ocular hypertension, therefore the up-regulation of alpha-ENaC proteins could serve as a protection mechanism against elevated intraocular pressure (6).
- ID gène
- 24768
- NCBI Accession
- NP_058742
- UniProt
- P37091
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