CDK5R1 anticorps (Atto 594)
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- Antigène Voir toutes CDK5R1 Anticorps
- CDK5R1 (Cyclin-Dependent Kinase 5, Regulatory Subunit 1 (p35) (CDK5R1))
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Reactivité
- Humain
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp CDK5R1 est conjugé à/à la Atto 594
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP), Immunocytochemistry (ICC), Antibody Array (AA)
- Specificité
- Detects ~23 kDa.
- Réactivité croisée
- Poulet, Cobaye, Humain, Souris, Lapin, Saccharomyces cerevisiae
- Purification
- Protein G Purified
- Immunogène
- Recombinant human full length p23 protein
- Clone
- JJ6
- Isotype
- IgG1
- Top Product
- Discover our top product CDK5R1 Anticorps primaire
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- Indications d'application
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- WB (1:2000) IHC (1:100)
- ICC/IF (1:100)
- optimal dilutions for assays should be determined by the user.
- Commentaires
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0.5 μg/ml of ABIN2486454 was sufficient for detection of p23 in 20 μg of heat shocked cell lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- PBS, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C
- Stockage commentaire
- Conjugated antibodies should be stored at 4°C
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- Antigène
- CDK5R1 (Cyclin-Dependent Kinase 5, Regulatory Subunit 1 (p35) (CDK5R1))
- Autre désignation
- p23 (CDK5R1 Produits)
- Synonymes
- anticorps CDK5P35, anticorps CDK5R, anticorps NCK5A, anticorps p23, anticorps p25, anticorps p35, anticorps p35nck5a, anticorps cdk5r1, anticorps zgc:92814, anticorps CDK5R1, anticorps Cdk5r, anticorps P25/P35, anticorps D11Bwg0379e, anticorps Xp35.1, anticorps cyclin dependent kinase 5 regulatory subunit 1, anticorps cyclin-dependent kinase 5, regulatory subunit 1b (p35), anticorps cyclin-dependent kinase 5 regulatory subunit 1, anticorps S100 calcium binding protein A9, anticorps cyclin-dependent kinase 5, regulatory subunit 1 (p35), anticorps cyclin-dependent kinase 5, regulatory subunit 1 (p35) L homeolog, anticorps CDK5R1, anticorps cdk5r1b, anticorps Cdk5r1, anticorps S100A9, anticorps cdk5r1.L
- Sujet
- P23 is a highly conserved ubiquitous protein, known to have an important function as a cochaperone for the HSP90 chaperoning system (1). Studies have revealed that p23 is a small protein (18 to 25 kDa) with a simple structure (2, 3). p23 does not have any structural homology with any other known proteins (1). p23 was first discovered as a part of the HSP90-progesterone receptor complex along with HSP70, p54 and p50 (1). p23 is a phosphor-protein, which is highly acidic and has an aspartic acid-rich c-terminal domain (1). Numerous studies have found p23 to be associated with other client proteins like Fes tyrosine kinase (4), the heme regulated kinase HRI (5), hsf1 transcription factor (4), aryl hydrocarbon receptor (4), telomerase (6), and Hepadnavirus reverse transcriptase (7). In spite of several years of study, the exact functional significance of p23 is still not clear (8). p23 is thought to be involved in the adenosine triphosphate-mediated HSP90 binding of client proteins (8). Since many HSP90 client proteins are involved in oncogenic survival signaling, a recent study has concluded p23 to be a promising target in leukemic apoptosis (9). HSP90 and its co-chaperone p23 are certainly among the emerging anti-tumor targets in oncology.
- ID gène
- 10728
- NCBI Accession
- NP_006592
- UniProt
- Q15185
- Pathways
- Stem Cell Maintenance, Regulation of Cell Size, Positive Regulation of Endopeptidase Activity
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