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CDK5R1 anticorps (PerCP)

CDK5R1 Reactivité: Humain WB, ELISA, IHC, IF, IP, ICC, AA Hôte: Souris Monoclonal JJ6 PerCP
N° du produit ABIN2486465
  • Antigène Voir toutes CDK5R1 Anticorps
    CDK5R1 (Cyclin-Dependent Kinase 5, Regulatory Subunit 1 (p35) (CDK5R1))
    Reactivité
    • 60
    • 48
    • 21
    • 12
    • 11
    • 10
    • 10
    • 5
    • 2
    • 2
    • 2
    • 1
    • 1
    Humain
    Hôte
    • 52
    • 22
    • 1
    Souris
    Clonalité
    • 46
    • 29
    Monoclonal
    Conjugué
    • 26
    • 6
    • 5
    • 5
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp CDK5R1 est conjugé à/à la PerCP
    Application
    • 60
    • 43
    • 39
    • 21
    • 20
    • 13
    • 13
    • 12
    • 10
    • 10
    • 5
    • 3
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP), Immunocytochemistry (ICC), Antibody Array (AA)
    Specificité
    Detects ~23 kDa.
     Réactivité croisée
    Poulet, Cobaye, Humain, Souris, Lapin, Saccharomyces cerevisiae
    Purification
    Protein G Purified
    Immunogène
    Recombinant human full length p23 protein
    Clone
    JJ6
    Isotype
    IgG1
    Top Product
    Discover our top product CDK5R1 Anticorps primaire
  • Indications d'application
    • WB (1:2000) IHC (1:100)
    • ICC/IF (1:100)
    • optimal dilutions for assays should be determined by the user.
    Commentaires

    0.5 μg/ml of ABIN2486465 was sufficient for detection of p23 in 20 μg of heat shocked cell lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    PBS, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C
    Stockage commentaire
    Conjugated antibodies should be stored at 4°C
  • Antigène
    CDK5R1 (Cyclin-Dependent Kinase 5, Regulatory Subunit 1 (p35) (CDK5R1))
    Autre désignation
    p23 (CDK5R1 Produits)
    Synonymes
    anticorps CDK5P35, anticorps CDK5R, anticorps NCK5A, anticorps p23, anticorps p25, anticorps p35, anticorps p35nck5a, anticorps cdk5r1, anticorps zgc:92814, anticorps CDK5R1, anticorps Cdk5r, anticorps P25/P35, anticorps D11Bwg0379e, anticorps Xp35.1, anticorps cyclin dependent kinase 5 regulatory subunit 1, anticorps cyclin-dependent kinase 5, regulatory subunit 1b (p35), anticorps cyclin-dependent kinase 5 regulatory subunit 1, anticorps S100 calcium binding protein A9, anticorps cyclin-dependent kinase 5, regulatory subunit 1 (p35), anticorps cyclin-dependent kinase 5, regulatory subunit 1 (p35) L homeolog, anticorps CDK5R1, anticorps cdk5r1b, anticorps Cdk5r1, anticorps S100A9, anticorps cdk5r1.L
    Sujet
    P23 is a highly conserved ubiquitous protein, known to have an important function as a cochaperone for the HSP90 chaperoning system (1). Studies have revealed that p23 is a small protein (18 to 25 kDa) with a simple structure (2, 3). p23 does not have any structural homology with any other known proteins (1). p23 was first discovered as a part of the HSP90-progesterone receptor complex along with HSP70, p54 and p50 (1). p23 is a phosphor-protein, which is highly acidic and has an aspartic acid-rich c-terminal domain (1). Numerous studies have found p23 to be associated with other client proteins like Fes tyrosine kinase (4), the heme regulated kinase HRI (5), hsf1 transcription factor (4), aryl hydrocarbon receptor (4), telomerase (6), and Hepadnavirus reverse transcriptase (7). In spite of several years of study, the exact functional significance of p23 is still not clear (8). p23 is thought to be involved in the adenosine triphosphate-mediated HSP90 binding of client proteins (8). Since many HSP90 client proteins are involved in oncogenic survival signaling, a recent study has concluded p23 to be a promising target in leukemic apoptosis (9). HSP90 and its co-chaperone p23 are certainly among the emerging anti-tumor targets in oncology.
    ID gène
    10728
    NCBI Accession
    NP_006592
    UniProt
    Q15185
    Pathways
    Stem Cell Maintenance, Regulation of Cell Size, Positive Regulation of Endopeptidase Activity
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