Heat Shock Protein 90kDa alpha (Cytosolic), Class B Member 1 (HSP90AB1) anticorps (Biotin)

Détails pour le produit réf. ABIN2486707
Antigène
  • D6S182
  • HSP84
  • HSP90B
  • HSPC2
  • HSPCB
  • GRP94
  • TRA1
  • hsp90b
  • 90kDa
  • AL022974
  • C81438
  • Hsp84
  • Hsp84-1
  • Hsp90
  • Hspcb
  • HSP90-BETA
  • hsp90beta
  • wu:fa29f01
  • wu:fa91e11
  • wu:fd59e11
  • wu:gcd22h07
  • HSP90
  • heat shock protein 90 alpha family class B member 1
  • heat shock protein 90 beta family member 1
  • Heat Shock Protein 90, endoplasmic reticulum
  • heat shock protein 90B
  • heat shock protein 90 alpha (cytosolic), class B member 1
  • heat shock protein 90kDa alpha family class B member 1 S homeolog
  • heat shock protein 90, alpha (cytosolic), class B member 1
  • HSP90AB1
  • HSP90B1
  • HSP90B
  • hsp90ab1
  • Hsp90ab1
  • hsp90ab1.S
Reactivité
Humain, Souris, Rat (Rattus)
324
238
199
35
22
18
15
10
9
8
8
7
5
3
2
1
1
1
1
1
1
1
Hôte
Lapin
236
87
1
Clonalité
Polyclonal
Conjugué
Biotin
13
8
8
8
8
8
8
6
5
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
Application
Immunocytochemistry (ICC), Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
266
146
134
85
62
49
42
41
14
14
6
5
3
3
1
1
Options
Immunogène Full length protein HSP90
Specificité Detects ~90kda. Does not cross-react with HSP90α.
Purification Peptide Affinity Purified
Antigène
Autre désignation HSP90 beta (HSP90AB1 Antibody Extrait)
Sujet HSP90 is a highly conserved and essential stress protein that is expressed in all eukaryotic cells. From a functional perspective, HSP90 participates in the folding, assembly, maturation, and stabilization of specific proteins as an integral component of a chaperone complex (1-4). Despite its label of being a heat-shock protein, HSP90 is one of the most highly expressed proteins in unstressed cells (1-2 % of cytosolic protein). It carries out a number of housekeeping functions - including controlling the activity, turnover, and trafficking of a variety of proteins. Most of the HSP90-regulated proteins that have been discovered to date are involved in cell signaling (5-6). The number of proteins now know to interact with HSP90 is about 100. Target proteins include the kinases v-Src, Wee1, and c-Raf, transcriptional regulators such as p53 and steroid receptors, and the polymerases of the hepatitis B virus and telomerase.5. When bound to ATP, HSP90 interacts with co-chaperones Cdc37, p23, and an assortment of immunophilin-like proteins, forming a complex that stabilizes and protects target proteins from proteasomal degradation. In most cases, HSP90-interacting proteins have been shown to co-precipitate with HSP90 when carrying out immunoadsorption studies, and to exist in cytosolic heterocomplexes with it. In a number of cases, variations in HSP90 expression or HSP90 mutation has been shown to degrade signaling function via the protein or to impair a specific function of the protein (such as steroid binding, kinase activity) in vivo. Ansamycin antibiotics, such as geldanamycin and radicicol, inhibit HSP90 function (7). Looking for more information on HSP90? Visit our new HSP90 Scientific Resource Guide at http://www.HSP90.ca.
ID gène 3326
NCBI Accession NP_031381
UniProt P08238
Pathways Regulation of Cell Size
Indications d'application
  • WB (1:1000)
  • IHC (1:100)
  • ICC/IF (1:120)
  • optimal dilutions for assays should be determined by the user.
Commentaires

A 1:1000 dilution of ABIN2486707 was sufficient for detection of HSP90 in 20 μg of HeLa cell lysate by ECL immunoblot analysis.

Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide
Agent conservateur Sodium azide
Précaution d'utilisation This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Stock -20 °C
Images (Fournisseur)
Image no. 1 for anti-Heat Shock Protein 90kDa alpha (Cytosolic), Class B Member 1 (HSP90AB1) antibody (Biotin) (ABIN2486707) Immunocytochemistry/Immunofluorescence analysis using Rabbit Anti-Hsp90 beta Polyclon...
Image no. 2 for anti-Heat Shock Protein 90kDa alpha (Cytosolic), Class B Member 1 (HSP90AB1) antibody (Biotin) (ABIN2486707) Western blot analysis of Human Cell line lysates showing detection of HSP90 beta prot...
Image no. 3 for anti-Heat Shock Protein 90kDa alpha (Cytosolic), Class B Member 1 (HSP90AB1) antibody (Biotin) (ABIN2486707) Immunohistochemistry analysis using Rabbit Anti-HSP90 beta Polyclonal Antibody . Tiss...
Image no. 4 for anti-Heat Shock Protein 90kDa alpha (Cytosolic), Class B Member 1 (HSP90AB1) antibody (Biotin) (ABIN2486707) Immunocytochemistry/Immunofluorescence analysis using Rabbit Anti-Hsp90 beta Polyclon...
Image no. 5 for anti-Heat Shock Protein 90kDa alpha (Cytosolic), Class B Member 1 (HSP90AB1) antibody (Biotin) (ABIN2486707) Western blot analysis of Human Cell line lysates showing detection of HSP90 beta prot...
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