MAPKBP1 anticorps
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- Antigène Voir toutes MAPKBP1 Anticorps
- MAPKBP1 (Mitogen-Activated Protein Kinase Binding Protein 1 (MAPKBP1))
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Reactivité
- Humain, Souris, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp MAPKBP1 est non-conjugé
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Application
- Western Blotting (WB), Immunohistochemistry (IHC)
- Purification
- Affinity purification
- Immunogène
- A synthetic peptide of human MAPKBP1
- Isotype
- IgG
- Top Product
- Discover our top product MAPKBP1 Anticorps primaire
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- Indications d'application
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WB 1:200 - 1:500
IHC 1:50 - 1:100 - Commentaires
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Expressed in intestinal mucosa, where it is detected in epithelial cells, endothelial cells, smooth muscle cells and immune cells, such as lymphocytes
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freeze/thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20C. Avoid freeze / thaw cycles.
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- Antigène
- MAPKBP1 (Mitogen-Activated Protein Kinase Binding Protein 1 (MAPKBP1))
- Autre désignation
- MAPKBP1 (MAPKBP1 Produits)
- Synonymes
- anticorps MGC83682, anticorps JNKBP-1, anticorps 2810483F24Rik, anticorps AW123212, anticorps Jnkbp1, anticorps mKIAA0596, anticorps mitogen-activated protein kinase binding protein 1 L homeolog, anticorps mitogen-activated protein kinase binding protein 1, anticorps mitogen activated protein kinase binding protein 1, anticorps mapkbp1.L, anticorps MAPKBP1, anticorps Mapkbp1
- Sujet
- This gene encodes a scaffold protein that regulates the JNK (c-Jun N-terminal kinase) and NOD2 (nucleotide-binding oligomerization domain-containing protein 2) signaling pathways. The encoded protein interacts with another related JNK pathway scaffold protein, WDR62, via a conserved dimerization domain, and enhances JNK signaling. This protein may play a role in bacterial immunity by binding to the NOD2 receptor and negatively regulating downstream antibacterial and pro-inflammatory signaling. Mutations in this gene that impair cellular localization of the encoded protein cause a form of nephronophthisis, an autosomal-recessive kidney disorder, in human patients.
- Poids moléculaire
- 163.818 kDa
- ID gène
- 23005
- UniProt
- O60336
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